{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:06:14Z","timestamp":1780632374643,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the diagnostic utility of abdominal shear wave elastography (SWE) in pediatric celiac disease (CD) by assessing mesenteric and terminal ileal stiffness and its association with serologic activity, histologic severity, and gluten\u2010free diet (GFD) duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective study, 84 children with CD and 80 matched healthy controls were evaluated. Mesenteric and terminal ileal stiffness values were measured using SWE. CD patients were stratified by GFD duration (short\u2010term: \u22646 months vs. long\u2010term: &gt;6 months) and tissue transglutaminase immunoglobulin A (tTG\u2010IgA) levels. Diagnostic performance was determined using receiver operating characteristic (ROC) curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mesenteric and ileal SWE values were significantly higher in CD patients than controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for both). Mesenteric stiffness demonstrated an area under the ROC curve (AUC) of 0.81 with an optimal cut\u2010off of 9.03\u2009kPa, while ileal stiffness showed an AUC of 0.83 with a cut\u2010off of 9.71\u2009kPa. Subgroup analysis revealed no significant difference in baseline Marsh scores between the short\u2010term and long\u2010term GFD groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.305), despite a dramatic decline in tTG\u2010IgA levels in the long\u2010term group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Elevated stiffness persisted in both newly diagnosed and GFD\u2010treated patients compared with controls (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No significant correlations were observed between SWE values and concurrent tTG\u2010IgA levels or Marsh subtypes (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Increased mesenteric and ileal stiffness in children with CD likely reflect transmural involvement and structural remodeling beyond the mucosal injury. These findings demonstrate that SWE has good diagnostic utility and may serve as a valuable complementary noninvasive tool in the evaluation and clinical monitoring of pediatric CD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70400","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:39:17Z","timestamp":1773725957000},"page":"1458-1465","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic utility of shear wave elastography in pediatric celiac disease: Assessment of mesenteric and ileal stiffness"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3689-6852","authenticated-orcid":false,"given":"Yasin Maruf","family":"Ergen","sequence":"first","affiliation":[{"name":"Department of Pediatrics\/Division of Pediatric Gastroenterology G\u00fclhane Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8878-9568","authenticated-orcid":false,"given":"Tu\u011fba","family":"\u00c7avi\u015f","sequence":"additional","affiliation":[{"name":"Department of Radiology G\u00fclhane Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1885-6611","authenticated-orcid":false,"given":"Sel\u00e7uk","family":"Teke","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Division of Pediatric Gastroenterology G\u00fclhane Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3165-3234","authenticated-orcid":false,"given":"Edibe G\u00f6zde","family":"Ba\u015faran","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Division of Pediatric Gastroenterology G\u00fclhane Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1325-0899","authenticated-orcid":false,"given":"Birce \u0130zgi","family":"Ak\u00e7ay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Division of Pediatric Gastroenterology G\u00fclhane Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8665-5611","authenticated-orcid":false,"given":"Necati","family":"Balamtekin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Division of Pediatric Gastroenterology G\u00fclhane Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.314105215"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-023-00907-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199910000-00019"},{"issue":"1","key":"e_1_2_9_6_1","article-title":"Peyer\u2032 s patches: the immune sensors of the intestine","volume":"2010","author":"Jung C","year":"2010","journal-title":"Int J Inflammation"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060227"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13213302"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1335205"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.230122"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000684"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-20-877"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2023.110807"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2021-323250"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14183696"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i15.2635"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.32074\/1591-951X-157"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-023-00543-y"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.09.006"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70400","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70400","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:22:54Z","timestamp":1780629774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,16]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jpn3.70400"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70400","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,16]]}}}