{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:06:32Z","timestamp":1780632392232,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Dysbiosis due to early\u2010life antibiotics may contribute to the development of functional gastrointestinal disorders (FGIDs). This follow\u2010up study of a birth cohort primarily investigates the association between antibiotic treatment in the first week of life and the presence of FGIDs at 9\u201312 years. Secondarily, it examines whether a history of infantile colic or current food allergy is associated with FGIDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective observational birth cohort of 436 term\u2010born infants was followed up at the age of 9\u201312 years; 151 received intravenous antibiotics in the first week of life due to suspected early onset sepsis (AB+) and 285 did not (AB\u2212). Participants filled out questionnaires on the presence of FGIDs (Rome IV questionnaire) and food allergies, and FGID diagnoses were reported by general practitioners. Statistical analyses included chi\u2010squared tests and multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three hundred and six of 388 eligible participants (79.5%) participated in the follow\u2010up study: 109 (35.6%) AB+ and 197 (64.4%) AB\u2212. FGID prevalence at 9\u201312 years was similar in AB+ and AB\u2212 (any FGID: odds ratio [OR] 1.083, 95% confidence interval [CI] 0.608\u20131.932). Infantile colic was not significantly associated with FAPDs after adjusting for confounders (adjusted OR 2.007, 95% CI 0.978\u20134.003,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.051). Children with a food allergy were more likely to have a functional abdominal pain disorder (FAPD) (adjusted OR 4.028, 95% CI 1.532\u201310.286).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>No statistically significant association was observed between first\u2010week antibiotics or infantile colic and FGIDs at 9\u201312 years of age, but FAPDs were significantly more prevalent in children with food allergies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70402","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:30:14Z","timestamp":1774323014000},"page":"1400-1407","source":"Crossref","is-referenced-by-count":0,"title":["Antibiotics in the first week of life are not associated with functional gastrointestinal disorders at 9\u201312 years of age"],"prefix":"10.1002","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0260-6992","authenticated-orcid":false,"given":"Nora C.","family":"Carpay","sequence":"first","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Department of Paediatrics, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam Reproduction and Development Research Institute Amsterdam the Netherlands"},{"name":"Department of Paediatrics St Antonius Hospital Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7081-9180","authenticated-orcid":false,"given":"Kim","family":"Kamphorst","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Deventer Hospital Deventer the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0310-6540","authenticated-orcid":false,"given":"Ruurd M.","family":"van Elburg","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Department of Paediatrics, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam Reproduction and Development Research Institute Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3869-2896","authenticated-orcid":false,"given":"Arine M.","family":"Vlieger","sequence":"additional","affiliation":[{"name":"Department of Paediatrics St Antonius Hospital Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00222-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10215087"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.595531"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2018.1438188"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13062056"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.17215"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15030615"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-015-0519-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2021-322861"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12857"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14829"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003428"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2021-001028"},{"issue":"3","key":"e_1_2_8_15_1","first-page":"193","article-title":"The 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