{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T06:02:59Z","timestamp":1785132179028,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>5\u2010Aminosalicylic acid (5\u2010ASA) is recommended as a first\u2010line medication in mild to moderate ulcerative colitis (UC), but indications regarding its use in children with moderate to severe disease treated with biologics are lacking. We aimed to evaluate the impact of discontinuing 5\u2010ASA in children with UC treated with anti\u2010tumor necrosis factor (anti\u2010TNF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective, multicenter, case\u2013control study of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition inflammatory bowel disease (IBD) study group. Children with UC starting anti\u2010TNF therapy between January 2018 and January 2023 and with a minimum follow of 6 months were included. Those who discontinued 5\u2010ASA (cases) were compared to those who continued mesalamine (controls). A Propensity Score analysis was used to match 1:2 with patients by baseline clinical and demographic characteristics. Every 6 months, during a 2\u2010year follow\u2010up, data on disease flares, IBD\u2010related hospitalization, surgery, need for step\u2010up treatment and acute severe colitis were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data from 298 children were collected (92 [31%] cases and 206 [69%] controls) and 227 were included in the final analysis after matching (85 [37.5%] cases and 142 [62.5%] controls]. Children who discontinued 5\u2010ASA were at higher risk of courses of steroids (Log\u2010Rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and hospitalization (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08). At the multivariate Cox regression analysis, 5\u2010ASA discontinuation was identified as an independent predictor of courses of steroids (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and hospitalization (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>5\u2010ASA discontinuation might negatively impact the clinical course of children with UC treated with anti\u2010TNF. Considering the good safety profile of the drug, continuing mesalamine can be suggested as a prudent approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70415","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:44:17Z","timestamp":1774511057000},"page":"96-107","source":"Crossref","is-referenced-by-count":0,"title":["Impact of 5\u2010Aminosalicylic acid discontinuation in children with ulcerative colitis on biologic therapy: A propensity score\u2010matched study"],"prefix":"10.1002","volume":"83","author":[{"given":"Giulia","family":"D'Arcangelo","sequence":"first","affiliation":[{"name":"Gastroenterology, Hepatology and Cystic Fibrosis Unit, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Scarallo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Nutrition Unit Meyer Children's Hospital IRCCS Florence Italy"},{"name":"Department of NEUROFARBA, Meyer Children's Hospital University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology and Liver Unit Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Corpino","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology Ospedale Paediatrico Microcitemico A. Cao, ARNAS Brotzu Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Human Pathology in Adulthood and Childhood \u201cG. Barresi\u201d, Paediatric Gastroenterology Unit University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Norsa","sequence":"additional","affiliation":[{"name":"Vittore Buzzi Children's Hospital University of Milan Milan Italy"},{"name":"Department of Paediatrics, Paediatric Hepatology, Gastroenterology and Transplantation ASST Papa Giovanni XXIII Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Arrigo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bramuzzo","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Health IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Fioretti","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science, Section of Paediatrics University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Zuin","sequence":"additional","affiliation":[{"name":"Paediatrics, Fondazione IRCCS San Gerardo dei Tintori Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Illiceto","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology and Endoscopy Unit, S Spirito Hospital Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Lionetti","sequence":"additional","affiliation":[{"name":"Gastroenterology and Nutrition Unit Meyer Children's Hospital IRCCS Florence Italy"},{"name":"Department of NEUROFARBA, Meyer Children's Hospital University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7404-4004","authenticated-orcid":false,"given":"Marina","family":"Aloi","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology and Cystic Fibrosis Unit, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico di Milano Milan Italy"},{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"527","article-title":"Once\u2010 versus twice\u2010daily mesalazine to induce remission in paediatric ulcerative colitis: a randomised controlled trial","volume":"11","author":"Turner D","year":"2017","journal-title":"J Crohn's 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