{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T06:02:57Z","timestamp":1785132177107,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Acute severe colitis (ASC) is a frequent and severe complication of ulcerative colitis (UC) with a high risk of colectomy. Effects of immunosuppressants and anti\u2013tumor necrosis factor (anti\u2010TNF) agents on the risk of colectomy remain debated. We wished to study the evolution of French pediatric\u2010onset UC patients after ASC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study was conducted in 12 French centers of the GETAID p\u00e9diatrique group. Data on patients with UC aged &lt;18 years admitted with ASC (defined as Pediatric Ulcerative Colitis Activity Index [PUCAI] score\u2009\u2265\u200965) between January 2010 and December 2020 were collected at discharge and at 1, 3, and 5 years after admission. The primary outcome was colectomy\u2010free rates at 1 year. Uni\u2010 and multivariate analyses were performed to identify prognostic factors associated with the risk of surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 102 patients admitted with ASC, 95 (93%) were treated with corticosteroids. Forty\u2010eight (50%) patients were escalated to second\u2010line therapy, mainly to infliximab. Nine patients (8.8%) underwent colectomy before discharge. Colectomy\u2010free survival rates were 82% at 1 year, 76% at 3 years, and 74% at 5 years. Patients without colectomy were in clinical and biological remission for a long time. In multivariate analysis, new onset UC, treatment with azathioprine or anti\u2010TNF agent, were significantly associated with a lower risk of colectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The rate of colectomy decreases but remains high after an episode of acute colitis despite early use of biotherapies. But long\u2010term outcome of pediatric\u2010onset UC patients seems good with sustained clinical and biological remission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70433","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:24:32Z","timestamp":1775211872000},"page":"117-126","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term outcomes of children with ulcerative colitis after acute severe colitis: A GETAID p\u00e9diatrique multicenter study"],"prefix":"10.1002","volume":"83","author":[{"given":"Manon","family":"Cochet","sequence":"first","affiliation":[{"name":"Service de Gastro\u2010ent\u00e9rologie et Nutrition p\u00e9diatrique Centre de R\u00e9f\u00e9rence des Maladies rares digestives (MARDI), Assistance Publique\u2014H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants malades, Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Beauvais","sequence":"additional","affiliation":[{"name":"Service des urgences adultes, APHP H\u00f4pital Saint\u2010Antoine, Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Ruemmele","sequence":"additional","affiliation":[{"name":"Service de Gastro\u2010ent\u00e9rologie et Nutrition p\u00e9diatrique Centre de R\u00e9f\u00e9rence des Maladies rares digestives (MARDI), Assistance Publique\u2014H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants malades, Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"INSERM UMR 1163 Immunit\u00e9 intestinale, Institut Imagine Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Enaud","sequence":"additional","affiliation":[{"name":"Service de Gastro\u2010ent\u00e9rologie et Nutrition p\u00e9diatrique CHU de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Lamireau","sequence":"additional","affiliation":[{"name":"Service de Gastro\u2010ent\u00e9rologie et Nutrition p\u00e9diatrique CHU de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Duclaux\u2010Loras","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9patologie Gastroent\u00e9rologie Nutrition H\u00f4pital Femme M\u00e8re Enfant Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Dupont","sequence":"additional","affiliation":[{"name":"Service de p\u00e9diatrie m\u00e9dicale CHU de Caen Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Willot","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Centre Universitaire R\u00e9gional de Tours \u2010 Clocheville Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Bridoux\u2010Henno","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie, Centre de R\u00e9f\u00e9rence des Maladies rares digestives (MARDI) CHU de Rennes\u2014H\u00f4pital Sud Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Dimitrov","sequence":"additional","affiliation":[{"name":"Service de chirurgie p\u00e9diatrique et p\u00e9diatrie CHR d'Orl\u00e9ans Orl\u00e9ans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Lemale","sequence":"additional","affiliation":[{"name":"Service de Nutrition et Gastro\u2010Ent\u00e9rologie p\u00e9diatrique Centre de R\u00e9f\u00e9rence des Maladies rares digestives (MARDI), H\u00f4pital Trousseau, Assistance Publique\u2014H\u00f4pitaux de Paris? Universit\u00e9 Paris Sorbonne Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Guinard\u2010Samuel","sequence":"additional","affiliation":[{"name":"Service de Nutrition et Gastro\u2010Ent\u00e9rologie p\u00e9diatrique Centre de R\u00e9f\u00e9rence des Maladies rares digestives (MARDI), H\u00f4pital Trousseau, Assistance Publique\u2014H\u00f4pitaux de Paris? Universit\u00e9 Paris Sorbonne Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Bertrand","sequence":"additional","affiliation":[{"name":"P\u00e9diatrie m\u00e9dicale Groupe Hospitalier du Havre\u2014Centre Hospitalier Jacques Monod Le Havre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Breton","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie\u2014Gastro\u2010ent\u00e9rologie, h\u00e9patologie, nutrition et diab\u00e9tologie CHU de Toulouse\u2014H\u00f4pital des Enfant Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Martinez","family":"Vinson","sequence":"additional","affiliation":[{"name":"Service de Maladies digestives et respiratoires de l'enfant Centre de R\u00e9f\u00e9rence des Maladies rares digestives (MARDI), CHU Robert Debr\u00e9, APHP, Universit\u00e9 Paris Cit\u00e9 Paris 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