{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T06:02:58Z","timestamp":1785132178399,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Previous studies on chronic pediatric\u2010onset conditions have highlighted the risks of loss to follow\u2010up, disease progression, or therapeutic nonadherence during transition. However, very few studies have focused on liver diseases. We aimed to evaluate the rate of successful transition in a cohort of patients with chronic liver disease, and assess its evolution over time and factors associated with transition failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an observational, retrospective, monocentric study at our tertiary hospital. Ninety\u2010three patients attending the pediatric hepatology clinic who were transferred to the adult\u2010oriented hepatology clinic between 1997 and 2019 with at least 2 years of follow\u2010up after transfer were included. Transition failure was defined as death, a history of poor medical office visit attendance, or complications due to therapeutic nonadherence within 2 years after transfer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of transition failure was 24%. Of this, poor attendance was 68% and complication was 32%, no deaths. The failure rate of transition decreased by almost 80% over time. A history of therapeutic nonadherence (odds ratio (OR)\u2009=\u20093.49; confidence interval (CI) 1.17\u201310.43,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and nonattendance to at least one pediatric consultation (OR\u2009=\u20092.76; CI 1.06\u20137.15,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) in the year before transfer were the only risk factors for transition failure. Significantly more patients in the success group than in the failure group had met an adult\u2010oriented hepatologist before transfer (31% vs. 9.1%, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transition was successful in more than three\u2010quarters of our cohort and even improved over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70436","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:51:23Z","timestamp":1776750683000},"page":"145-154","source":"Crossref","is-referenced-by-count":0,"title":["Success of transition to adult care in patients with pediatric\u2010onset chronic liver disease"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7876-9223","authenticated-orcid":false,"given":"Sarah","family":"Mongbo","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition Inserm U1286 Infinite, CHU Lille Universit\u00e9 de Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Canva","sequence":"additional","affiliation":[{"name":"CHU Lille, Unit of Gastroenterology and Hepatology, Inserm U1286 Infinite Universit\u00e9 de Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Dharancy","sequence":"additional","affiliation":[{"name":"CHU Lille, Unit of Gastroenterology and Hepatology, Inserm U1286 Infinite Universit\u00e9 de Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Lassailly","sequence":"additional","affiliation":[{"name":"CHU Lille, Unit of Gastroenterology and Hepatology, Inserm U1286 Infinite Universit\u00e9 de Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Louvet","sequence":"additional","affiliation":[{"name":"CHU Lille, Unit of Gastroenterology and Hepatology, Inserm U1286 Infinite Universit\u00e9 de Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Mathurin","sequence":"additional","affiliation":[{"name":"CHU Lille, Unit of Gastroenterology and Hepatology, Inserm U1286 Infinite Universit\u00e9 de Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassima","family":"Ramdane","sequence":"additional","affiliation":[{"name":"Department of Biostatistics CHU Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Gottrand","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition Inserm U1286 Infinite, CHU Lille Universit\u00e9 de Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Aumar","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Hepatology and Nutrition Inserm U1286 Infinite, CHU Lille Universit\u00e9 de Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-233700"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002938"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.3.e197"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1450"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60370-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12549"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-8-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2007.00689.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002553"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003549"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003013"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24870"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12746"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-020-01717-y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003581"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2016.07.006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12053"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2018.05.009"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2019.07.018"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.2019-0172"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24044"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-2413"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002568"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31829ef82c"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001930"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2017.10.013"},{"key":"e_1_2_8_28_1","first-page":"349","article-title":"Overall quality of life in adult biliary atresia survivors with or without liver transplantation: results from a National Cohort","volume":"26","author":"Vries W","year":"2016","journal-title":"Eur J Pediatr Surg"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13331"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04181.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsx142"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2020.08.021"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2015.04.012"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.07.031"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.05.066"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70436","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70436","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:57:49Z","timestamp":1785131869000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/jpn3.70436"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70436","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]}}}