{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:53Z","timestamp":1786978133836,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015738","name":"Mary och Georg C. Ehrnrooths Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007797","name":"Helsingin Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We evaluated the efficacy and safety of teduglutide in a real\u2010world cohort in which national reimbursement policies required treatment interruptions. The primary outcomes were reduction in parenteral support (PS) and treatment\u2010related adverse effects, and the secondary outcome was the impact of the mandated withdrawal periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective registry\u2010based nationwide study, we identified all pediatric short bowel\u2013associated intestinal failure (IF) patients treated with teduglutide and reviewed clinical records to evaluate PS reduction and adverse effects during treatment and withdrawal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty pediatric IF patients had teduglutide initiated (age range: 1.4\u201317 years) between 2016 and 2022. Patients had a median 16% small bowel remaining, and 16 (79%) had the ileocecal valve removed. Children who continued teduglutide over 6 months (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919) had a median of 31 (range: 13\u201356) months of follow\u2010up on medication. Their median reductions in daily PS energy and fluid volume requirement were 42% and 28\u2009mL\/kg\/day, respectively. Weekly infusion\u2010free nights increased from 0.5 to 4. Seventeen (89%) patients reached &gt;20% energy reduction. Six patients (32%) successfully weaned off PS. Four patients (20%) experienced intestinal bleeding while on teduglutide. Stomal prolapses occurred in all patients with end\u2010jejunostomies. Periodic withdrawal (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937) led to adverse effects on 84% of occasions (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932), including two unplanned hospitalizations and 14 (38%) outpatient visits, dehydration in 19 (51%), and diarrhea in 28 (76%) occasions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Teduglutide resulted in clinically significant PS reduction and increased infusion\u2010free nights. The periodic withdrawal of teduglutide was harmful and should not be routinely employed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: HUS\/265\/2023.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70437","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:07:04Z","timestamp":1775732824000},"page":"37-45","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes and adverse effects of teduglutide treatment with periodic withdrawal in pediatric short bowel patients"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-4549","authenticated-orcid":false,"given":"Riikka","family":"Gunnar","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology Unit Helsinki University Children's Hospital Helsinki Finland"},{"name":"The Pediatric Research Center University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Mutanen","sequence":"additional","affiliation":[{"name":"The Pediatric Research Center University of Helsinki Helsinki Finland"},{"name":"Pediatric Surgery Department Helsinki University Children's Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko P.","family":"Pakarinen","sequence":"additional","affiliation":[{"name":"The Pediatric Research Center University of Helsinki Helsinki Finland"},{"name":"Pediatric Surgery Department Helsinki University Children's Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Merras\u2010Salmio","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Helsinki University Children's Hospital Helsinki Finland"},{"name":"The Pediatric Research Center University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003894"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002529"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.864397"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.26.061505.111223"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00588.2005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10102061"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1690"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2023.07.019"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14081634"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.01.031"},{"issue":"1","key":"e_1_2_8_12_1","first-page":"5","article-title":"Predicting 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