{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:09:43Z","timestamp":1787317783546,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Anti\u2010integrin \u03b1v\u03b26 Immunoglobulin G (anti\u2010\u03b1v\u03b26 IgG) has been identified as a biomarker for ulcerative colitis (UC) in adults, but they were also detected in pediatric Crohn's disease (CD). We hypothesized that their less specificity in this population could reflect colonic inflammation rather than disease type and may be influenced by HLA\u2010DQA1*05 carriage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a monocentric retrospective study using serum and clinical data from 213 pediatric inflammatory bowel disease patients and 110 controls, analyzing the association between anti\u2010\u03b1v\u03b26 IgG and disease location, clinical and endoscopic activity, and HLA\u2010DQA1*05 status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Anti\u2010\u03b1v\u03b26 IgG were detected in 80 of 105 patients (76%) with UC, 30 of 108 patients (28%) with CD, and 2 of 110 (2%) controls. In patients with CD, anti\u2010\u03b1v\u03b26 IgG positivity was significantly higher in colonic or ileocolonic phenotypes (29\/84; 35%) compared to ileal or upper gastrointestinal phenotypes (1\/24, 4%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0035). No significant association was found between antibody positivity or levels and clinical, biochemical or endoscopic activity. Anti\u2010\u03b1v\u03b26 IgG was detected in 73% of patients with UC and 23% of patients with CD in endoscopic remission. The HLA\u2010DQA1*05 allele was more frequent in antibody\u2010positive patients (78% vs. 56%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), though also more common in UC than CD (82% vs. 54%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In our cohort, among patients with CD, anti\u2010\u03b1v\u03b26 IgG autoantibodies were predominantly detected in those with colonic localization. This observation may support previous evidence of a shared immunological background between colonic CD and UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70444","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:38:12Z","timestamp":1776407892000},"page":"63-70","source":"Crossref","is-referenced-by-count":3,"title":["Anti\u2010integrin \u03b1v\u03b26 Immunoglobulin G antibodies are detected in pediatric colonic Crohn's disease"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9748-902X","authenticated-orcid":false,"given":"Fabiana","family":"Ziberna","sequence":"first","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Grigoletto","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigina De","family":"Leo","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Fontana","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Molinario","sequence":"additional","affiliation":[{"name":"University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia Di","family":"Leo","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bramuzzo","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4028-4194","authenticated-orcid":false,"given":"Sara","family":"Lega","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.02.019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80545-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2018.04.013"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11071881"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2023.06.024"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2024.102317"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.12.042"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaf062"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.06.026"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022-058037"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12121934"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00465-1"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae169"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2022-001003"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200523183"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01680-y"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2508023"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-003465"}],"container-title":["Journal 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