{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T06:02:56Z","timestamp":1785132176422,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize the clinical, histopathologic, and molecular\u2010genetic characteristics of Lynch syndrome (LS)\u2010associated gastrointestinal disease in the pediatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a scoping review, systematically searching PubMed and Embase\u00ae (from inception to October 16, 2025) and using controlled vocabulary and keywords, with additional screening of reference lists and conference abstracts. We included reports of gastrointestinal manifestations of LS in individuals &lt;21 years or pediatric subsets within mixed\u2010age cohorts; no language, date, or geographic restrictions were applied. Titles\/abstracts and full texts were independently screened. Data were abstracted for demographics, presentation, gastrointestinal phenotype, tumor characteristics, mismatch repair immunohistochemistry, genotype, management, and outcomes. Findings were summarized descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010eight pediatric LS patients (age 12\u201321 years, mean 16; 26 male) were included. Gastrointestinal manifestations included colorectal cancer (CRC) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200944), adenomatous polyps (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095), gastric adenocarcinoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091), and jejunal adenocarcinoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091). CRCs were predominantly left\u2010sided (71%) and advanced at diagnosis (66% stage III\/IV). Right\u2010sided tumors were more common (3:1) in males whereas left\u2010sided tumors were evenly distributed. MMR gene variants were reported in 37 patients, dominated by\n                      <jats:italic>MLH1<\/jats:italic>\n                      (54%) and\n                      <jats:italic>MSH2<\/jats:italic>\n                      (32%), with fewer\n                      <jats:italic>MSH6<\/jats:italic>\n                      and\n                      <jats:italic>PMS2<\/jats:italic>\n                      variants (14%). Histology included conventional (69%), mucinous (22%), medullary (6%), and signet\u2010ring (3%) adenocarcinoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      LS confers risk for pediatric colorectal adenoma and cancer. CRC in this population manifests predominantly as left\u2010sided, advanced\u2010stage CRC, driven by loss\u2010of\u2010function variants in\n                      <jats:italic>MLH1<\/jats:italic>\n                      and\n                      <jats:italic>MSH2<\/jats:italic>\n                      . These findings contrast with the right\u2010sided predominant adult LS and suggest age\u2010specific biology. Increased awareness and further research are needed to inform age\u2010appropriate surveillance strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70445","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:44:32Z","timestamp":1776750272000},"page":"7-13","source":"Crossref","is-referenced-by-count":0,"title":["Pediatric Lynch syndrome: Clinical, genotypic, and left\u2010sided patterns of colorectal cancer"],"prefix":"10.1002","volume":"83","author":[{"given":"Claudia","family":"Phen","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Rojas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunter J.","family":"Friesen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Missouri\u2010Kansas City School of Medicine Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keri","family":"Swaggart","sequence":"additional","affiliation":[{"name":"Library Services, Children's Mercy Hospital Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen B.","family":"Flahive","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Nationwide Children's Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne P.","family":"MacFarland","sequence":"additional","affiliation":[{"name":"Division of Oncology Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-4437","authenticated-orcid":false,"given":"Thomas","family":"Attard","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Children's Mercy Hospital Kansas City Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"MohamedI AbosheaishaaH SalemA et al. 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