{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:12:24Z","timestamp":1788437544467,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010573","name":"Stichting Dioraphte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010573","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the feasibility and efficacy of fecal microbiota transplantation (FMT) in adolescents (16\u201321 years) with refractory irritable bowel syndrome (IBS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomized controlled pilot trial. Thirty\u2010two patients were included and randomized to receive two allogeneic or autologous FMTs. At baseline and after 6 weeks, two allogeneic or autologous FMTs were administered via a nasoduodenal tube. Feasibility outcomes included dropout rate. Clinical efficacy was evaluated by the proportion of responders (\u226550 points reduction in total score of the IBS severity\u2010scoring\u2010system) at 12, 24, and 48 weeks follow\u2010up. Secondary outcomes included health\u2010related quality of life (QoL), depression and anxiety scores, and school\/work absenteeism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One patient (3%) withdrew after randomization, due to lack of effect after the first FMT. Response rates 12 weeks after allogeneic and autologous FMTs were 40% and 38% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.886). At 24 weeks, significantly more patients responded after allogeneic FMTs (60% vs. 25% autologous,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048), without significant differences at 48 weeks (60% vs. 50%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.576). Total QoL score was significantly better after allogeneic than autologous FMTs at 12, 24, and 48 weeks (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). In the allogeneic FMTs group, school\/work absenteeism was 7% at 24 weeks (vs. 41% autologous,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Allogeneic FMTs were feasible and resulted in high response rates and better QoL compared to autologous FMTs. These results provide preliminary evidence for the use of allogeneic FMTs in adolescents with refractory IBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov identifier: NCT03074227 (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT03074227?id=NCT03074227%26rank=1\">https:\/\/clinicaltrials.gov\/study\/NCT03074227?id=NCT03074227&amp;rank=1<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70459","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:19:31Z","timestamp":1780305571000},"page":"381-389","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility and efficacy of fecal microbiota transplantation in adolescents with refractory irritable bowel syndrome: A randomized clinical pilot trial"],"prefix":"10.1002","volume":"83","author":[{"given":"Clara M. A.","family":"de Bruijn","sequence":"first","affiliation":[{"name":"Emma Children's Hospital, Amsterdam University Medical Centers University of Amsterdam, Pediatric Gastroenterology, Hepatology and Nutrition Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction &amp; Development Research Institute, Amsterdam University Medical Centers Location Academic Medical Center\/Emma Children's Hospital Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Centers University of Amsterdam, Gastroenterology and Hepatology Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6661-9493","authenticated-orcid":false,"given":"Anna O. J.","family":"Oorthuys","sequence":"additional","affiliation":[{"name":"Emma Children's Hospital, Amsterdam University Medical Centers University of Amsterdam, Pediatric Gastroenterology, Hepatology and Nutrition Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction &amp; Development Research Institute, Amsterdam University Medical Centers Location Academic Medical Center\/Emma Children's Hospital Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Centers University of Amsterdam, Gastroenterology and Hepatology Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Zeevenhooven","sequence":"additional","affiliation":[{"name":"Emma Children's Hospital, Amsterdam University Medical Centers University of Amsterdam, Pediatric Gastroenterology, Hepatology and Nutrition Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Davids","sequence":"additional","affiliation":[{"name":"Departments of Internal and Experimental Vascular Medicine Amsterdam University Medical Centers, Location Academic Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes H. 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