{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:17:05Z","timestamp":1788437825520,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Wilson disease (WD) and autoimmune hepatitis (AIH) are leading causes of chronic liver disease in children and often present with overlapping clinical and immunological features, complicating early diagnosis. This retrospective study evaluated serum immunoglobulin G (IgG) and autoantibody profiles in 79 genetically confirmed, treatment\u2010naive pediatric WD patients compared with 112 AIH controls. Elevated IgG (&gt;1.1\u00d7 upper limit of normal) was observed in 82.3% of WD patients, while 31.5% tested positive for at least one autoantibody, including anti\u2010smooth muscle antibody, anti\u2010nuclear antibody, and anti\u2010liver kidney microsomal. Notably, 20.2% of WD patients met the simplified diagnostic criteria for AIH. Compared to AIH, WD patients had significantly lower IgG levels and less frequent autoantibody positivity. Histology revealed distinguishing features, with WD showing more steatosis and ballooning but less interface hepatitis and plasma cell infiltration. These findings highlight the potential for diagnostic misclassification. Comprehensive evaluation, including histology and genetic testing, remains critical to differentiate WD from AIH and guide appropriate therapy.<\/jats:p>","DOI":"10.1002\/jpn3.70461","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T11:39:09Z","timestamp":1779709149000},"page":"241-246","source":"Crossref","is-referenced-by-count":0,"title":["False positive autoimmune markers and elevated immunoglobulin G in genetically confirmed Wilson disease"],"prefix":"10.1002","volume":"83","author":[{"given":"Ashray Sudarshan","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Pediatric Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samannay","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamoghna","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikrant","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6275-7736","authenticated-orcid":false,"given":"Bikrant Bihari","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"issue":"24","key":"e_1_2_8_2_1","article-title":"EASL\u2010ERN clinical practice guidelines on Wilson's disease","author":"European Association for the Study of the Liver","year":"2025","journal-title":"J 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