{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:12:15Z","timestamp":1788437535132,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Inflammatory bowel disease (IBD) and chronic nonbacterial osteomyelitis (CNO) is a rare association. Its prevalence is probably underestimated due to low awareness among clinicians. The aim of this study was to describe the French pediatric national cohort and to estimate the incidence of CNO among IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively collected all reports of IBD\u2010CNO association from pediatric gastroenterological and rheumatologic units between 2000 and 2024. We analyzed demographic data; age of the onset; IBD type; CNO localizations; dermatological lesions; explorations results; medications; follow\u2010up. Incidence was estimated using French regional inception population\u2010based cohort EPIMAD data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010seven patients were identified. Median age at the onset was 13.5 years (interquartile range [IQR] 11.5\u201314.5). CNO diagnosis preceded IBD in 11 cases, followed it in 13 cases, while 13 IBD\u2010CNO cases were diagnosed simultaneously (median interval 1 year). IBD included 25 Crohn's disease, 10 ulcerative colitis, 2 IBD\u2010unclassified. Bone localizations predominated in lower limbs and pelvis (75.3%). Fourteen children (37.8%) had dermatological lesions. At last follow\u2010up (median 3 years, IQR 1.25\u20134.75), 28 patients (75.7%) were in IBD\u2010CNO remission, having mostly anti\u2010tumor necrosis factor (TNF)\u2010\u03b1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041, 82.1% remission, 44.4% relapse) in monotherapy (60.7%). We estimate the incidence of this association among French pediatric IBD at 1 case for 20,000 patients\u2010year.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study describes a large national cohort of pediatric IBD\u2010CNO association. Gastroenterologist should request a whole body\u2010magnetic resonance imaging when IBD patients present chronic bone pain. Multidisciplinary management involving rheumatologists and dermatologists is recommended. Most patients responded to anti\u2010TNF\u2010\u03b1 antibodies, which could avoid bone complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70484","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T09:48:47Z","timestamp":1781603327000},"page":"456-466","source":"Crossref","is-referenced-by-count":0,"title":["Chronic nonbacterial osteomyelitis and inflammatory bowel disease in children: A French national cohort"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0225-9046","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Bertrand","sequence":"first","affiliation":[{"name":"D\u00e9partement de p\u00e9diatrie H\u00f4pital Jacques Monod, BP 24 Le Havre 76083 France"},{"name":"Univ Rouen Normandie, INSERM, Normandie Univ, ADEN UMR1073, Nutrition, Inflammation and microbiota\u2010gut\u2010brain axis Rouen F\u201076000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Pigneur","sequence":"additional","affiliation":[{"name":"INSERM UMR S 1139, Facult\u00e9 de Pharmacie de Paris Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"Service de Gastro\u2010ent\u00e9rologie et Nutrition p\u00e9diatrique, Centre de R\u00e9f\u00e9rence des Maladies rares digestives (MARDI) Assistance Publique \u2013 H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants malades, Universit\u00e9 Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Louise","family":"Fr\u00e9mond","sequence":"additional","affiliation":[{"name":"Paediatric Haematology\u2010Immunology and Rheumatology Unit Necker Hospital, AP\u2010HP, Universit\u00e9 Paris Cit\u00e9 and Reference Centre for Inflammatory Rheumatism, Autoimmune Diseases and Systemic Interferonopathies in Children (RAISE) Paris F\u201075015 France"},{"name":"Institut IMAGINE, INSERM 1163 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Coopman","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Lille Hospital Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damia","family":"Leguevaques","sequence":"additional","affiliation":[{"name":"Department of Paediatric Rheumatology Jeanne de Flandre Lille University Children's Hospital F\u201059000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrine","family":"Dusser","sequence":"additional","affiliation":[{"name":"Paediatric Rheumatology Service, Reference Centre for Auto\u2010Inflammatory Diseases and Amylosis Bic\u00eatre Hospital Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Breton","sequence":"additional","affiliation":[{"name":"Service de Gastroent\u00e9rologie, H\u00e9patologie, Nutrition et Maladies H\u00e9r\u00e9ditaires du M\u00e9tabolisme et Centre de R\u00e9f\u00e9rence des Maladies Rares Digestives H\u00f4pital des Enfants, CHU de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Benezech","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie P\u00e9diatrique H\u00f4pital des Enfants, CHU de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Rebelle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics H\u00f4pital Marseille Saint Joseph Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Sabard","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Centre Hospitalier R\u00e9gional Universitaire H\u00f4pital Clocheville Tours 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H\u00f4pital Robert Debr\u00e9, Service de Rhumatologie P\u00e9diatrique, RAISE Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"GETAID (Groupe d'Etude th\u00e9rapeutique des Affections Inflammatoires du Tube Digestif) p\u00e9diatrique; SOFREMIP (Soci\u00e9t\u00e9 Francophone de Rhumatologie Et de Maladie Inflammatoire P\u00e9diatrique)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199072020-00025"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/children10030502"},{"issue":"11","key":"e_1_2_8_4_1","first-page":"1992","article-title":"Data from a multicentric international study unveils a neglected association between chronic non\u2010bacterial osteomyelitis and inflammatory bowel diseases","volume":"43","author":"Matucci\u2010Cerinic 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