{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:12:15Z","timestamp":1788437535543,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Nutritional management is crucial for improving outcomes in children on prolonged mechanical ventilation (PMV); but detailed data are lacking. This study aimed to investigate the nutritional management of children on PMV in China and to explore their association with clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter prospective observational cohort study enrolled children (aged 28 days to 18 years) who received mechanical ventilation for\u2009\u2265\u200921 consecutive days (PMV) from 11 tertiary hospitals across China between April 2021 and September 2022. Data on demographics and nutritional indicators (including calorie intake, protein intake, and laboratory test) were collected at enrollment (Day 1), Day 14, and Day 28. Nutritional status was assessed using Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP) screening tool and World Health Organization (WHO) age\u2010specific Z\u2010scores. The primary outcome was in\u2010hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 296 children, in\u2010hospital mortality rate was 31.8%. All were at high nutritional risk at the time of enrollment, and 51.4% were malnourished. Non\u2010survivors received full enteral nutrition significantly less frequently than survivors at all time points (e.g., 58.5% vs. 82.2% at Day 1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Linear mixed models showed non\u2010survivors had persistently lower median caloric and protein intake (calories: 42.9 vs. 53.3\u2009kcal\/kg\/day; protein: 1.2 vs. 1.6\u2009g\/kg\/day; both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Hemoglobin levels were persistently lower in non\u2010survivors, with no significant difference in serum albumin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Children on prolonged mechanical ventilation are at high nutritional risk, with total parenteral nutrition, low caloric intake and protein intake, and low hemoglobin being more pronounced in non\u2010survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70489","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T07:15:21Z","timestamp":1782112521000},"page":"521-527","source":"Crossref","is-referenced-by-count":0,"title":["The relationship between nutritional management and prognosis in children on prolonged mechanical ventilation"],"prefix":"10.1002","volume":"83","author":[{"given":"Chunlin","family":"Xing","sequence":"first","affiliation":[{"name":"Department of Pediatric Intensive Care Unit Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-9316","authenticated-orcid":false,"given":"Zhengzheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, National Children's Medical Center, Children's Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit National Children's Medical Center for South Central Region, Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit National Children's Medical Center, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Emergency\/Critical Medicine Children's Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit Children's Hospital, Capital Institute of Pediatrics Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengmiao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, National Center for Children's Health, Beijing Children's hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit Children's Hospital Affiliated to Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, Wuhan Children\u2032s Hospital, Tongji Medical College Huazhong University of Science &amp; Technology Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, National Children's (Northeast) Regional Medical Center Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Liu","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, National Children's Medical Center, Children's Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, National Children's Medical Center, Children's Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Shenzhen Children's Hospital Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Lu","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, National Children's Medical Center, Children's Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4868-1602","authenticated-orcid":false,"given":"Weiming","family":"Chen","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, 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