{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:12:22Z","timestamp":1788437542290,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify risk factors for abdominal pain and predictors of complicated abdominal pain in pediatric immunoglobulin A vasculitis (IgAV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective multicenter study including children and adolescents (\u226418 years) fulfilling the European League Against Rheumatism\/Pediatric Rheumatology International Trials Organization\/Pediatric Rheumatology European Society (EULAR\/PRINTO\/PRES) criteria for IgAV and followed at four tertiary centers in Brazil. Factors associated with abdominal pain in the overall cohort and with complicated abdominal pain (defined as abdominal pain associated with intussusception, intestinal bleeding, or acute abdomen) were evaluated during the first 3 months of the disease and at the end of follow\u2010up. Univariate analyses, a pre\u2010specified multivariable log\u2010binomial regression model, and receiver operating characteristic (ROC) curve analysis were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 687 pediatric patients with IgAV, 420 (61.1%) developed abdominal pain within the first 3 months and 428 (62.3%) by the end of follow\u2010up (median follow\u2010up of 54.1 months [interquartile range 50.7\u201359.3]). Among patients with abdominal pain, 22.2% developed complications. Prolonged purpuric\/petechial rash (&gt;29 days; RRadj 1.78, 95% confidence interval [CI] 1.09\u20132.91) and leukocytosis (&gt;13,500\/mm\n                      <jats:sup>3<\/jats:sup>\n                      ; RRadj 2.30, 95% CI 1.41\u20133.73) were independently associated with complications. Leukocytosis showed good discriminatory performance for predicting acute abdomen (area under the curve 0.813, 95% CI 0.704\u20130.923).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prolonged purpuric\/petechial rash and leukocytosis were independently associated with complicated abdominal pain.\u00a0Leukocytosis may help identify children at higher risk of acute abdomen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70492","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:31:41Z","timestamp":1782919901000},"page":"412-421","source":"Crossref","is-referenced-by-count":0,"title":["Abdominal pain in pediatric immunoglobulin A vasculitis: Risk factors and severity predictors in a multicenter cohort"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6354-824X","authenticated-orcid":false,"given":"Francisco Hugo Rodrigues","family":"Gomes","sequence":"first","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4755-1518","authenticated-orcid":false,"given":"Natalia","family":"Maronese","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4936-5900","authenticated-orcid":false,"given":"Leticia Lizardo","family":"Magalhaes","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1019-3654","authenticated-orcid":false,"given":"Davi Casale","family":"Aragon","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7824-437X","authenticated-orcid":false,"given":"Gleice","family":"Clemente","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2496-4296","authenticated-orcid":false,"given":"Maria 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