{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:12:17Z","timestamp":1788437537969,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>End\u2010stage chronic liver disease in children is associated with sarcopenia and aberrant adipose tissue mass. We investigated correlations between liver pathology\u2010associated gene pathways (fibrosis, inflammation and steatosis) and metabolic genes in muscle and adipose tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Liver, rectus abdominis muscle and subcutaneous adipose tissue were collected during liver transplant for microarray gene expression analysis. Patients underwent pre\u2010transplant indirect calorimetry, anthropometry and laboratory assessments. Weighted gene co\u2010expression network analysis identified highly correlated gene modules within each tissue and explored inter\u2010tissue correlations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine patients were studied, three male:six female, age 7 months to 17 years. Liver gene clusters associated with fibrosis and ribosome function\/protein secretion negatively correlated with muscle mitochondrial function genes and positively correlated with adipose tissue mitochondrial function genes. Notable correlations included a negative correlation between muscle growth hormone receptor (GHR) and liver ARID5B, MFGE8 and YWHAZ, and a positive correlation between adipose AKT1, ADG5, and SRM and liver RRAGA, YES1, EIF3M and COX3A. Liver inflammation\u2010associated genes (vimentin, TIMP2, CXCL6 and endothelin\u20101) negatively correlated with adipose genes improving insulin sensitivity (THRSP) and fibrosis\u2010related genes (KRT36, DMTN). Liver steatosis genes (ADRA2B) negatively correlated with adipose genes involved in adipogenesis (FGF10) and thyroid hormone metabolism (NHLH1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Genes related to liver fibrosis and protein secretion negatively correlated with muscle and adipose tissue metabolism\/proliferation genes. Liver inflammation and steatosis gene clusters were associated with muscle and adipose metabolism genes. This pilot study highlights important inter\u2010tissue gene correlations warranting further investigation in paediatric end\u2010stage chronic liver disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70498","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T08:43:09Z","timestamp":1783327389000},"page":"500-508","source":"Crossref","is-referenced-by-count":0,"title":["Inter\u2010tissue relationships of gene expression in liver, muscle and adipose tissue of children with end\u2010stage chronic liver disease"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4696-4855","authenticated-orcid":false,"given":"Eirini","family":"Kyrana","sequence":"first","affiliation":[{"name":"Roger Williams Institute of Liver Studies King's College London London UK"},{"name":"Paediatric Liver, GI and Nutrition Centre and MowatLabs King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Roger Williams Institute of Liver Studies King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Jin","sequence":"additional","affiliation":[{"name":"Central Laboratory Tianjin Medical University General Hospital Tianjin China"},{"name":"Department of Pathology Maastricht University Medical Centre+ Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siamak","family":"Salehi","sequence":"additional","affiliation":[{"name":"Roger Williams Institute of Liver Studies King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan C. 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