{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:19:36Z","timestamp":1783329576228,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Potential celiac disease (PCD) is defined by positive celiac serology without villous atrophy. We aimed to study the outcome of children with PCD consuming a gluten\u2010containing diet (GCD) over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children diagnosed with PCD between December 2018 and January 2022, in three pediatric gastroenterology centers, were longitudinally followed. Data were collected until October 2024, with a minimum follow\u2010up of 12 months, unless celiac disease (CeD) was diagnosed earlier. Baseline data included demographics, celiac serology, and histological findings. Follow\u2010up data included serology and biopsy results when performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort included 88 patients with PCD, with a mean follow\u2010up of 39 (range 12\u2013 69) months. During this period, 17 (19.5%) patients progressed to CeD. Normalization of anti\u2010tissue transglutaminase antibodies (tTG), while continuing a GCD, occurred in 33\/88 (37.5%) while the rest remained with PCD. Specifically, among 16 patients with tTG levels &gt;\u00d710 upper limit of normal (ULN) at PCD diagnosis, three (18.8%) progressed to CeD, six (37.5%) normalized tTG while continued GCD, and the rest remained unchanged. Asymptomatic patients had higher rates of tTG normalization (61.9% vs. 35.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0011). Neither tTG levels, nor having Marsh 1 histology, had a significant effect on PCD outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among pediatric patients with PCD, during a mean follow\u2010up of 3.3 years, one\u2010fifth progressed to CeD. Baseline serology levels do not reliably predict future mucosal deterioration. Over a third of children with PCD may achieve serological normalization while maintaining a GCD. This heterogeneous pattern of PCD warrants periodic serological and histological follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70501","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T08:44:26Z","timestamp":1783327466000},"source":"Crossref","is-referenced-by-count":0,"title":["Heterogeneous outcomes in pediatric potential celiac disease: A multicenter longitudinal study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6425-4106","authenticated-orcid":false,"given":"Barak","family":"Laxer","sequence":"first","affiliation":[{"name":"Pediatric Division Kaplan Medical Center Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7634-5310","authenticated-orcid":false,"given":"Firas","family":"Rinawi","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Emek Medical Centre Afula Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadya","family":"Ziv\u2010Sokolovskaya","sequence":"additional","affiliation":[{"name":"Institute of Pathology Kaplan Medical Center Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raanan","family":"Shamir","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center of Israel Petach\u2010Tikva Israel"},{"name":"Gray Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Kori","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Kaplan Medical Center Rehovot Israel"},{"name":"Faculty of Medicine Hebrew University Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4175-7432","authenticated-orcid":false,"given":"Anat","family":"Guz\u2010Mark","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center of Israel Petach\u2010Tikva Israel"},{"name":"Gray Faculty of Medical &amp; Health Sciences Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"issue":"10344","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1016\/S0140-6736(22)00794-2","article-title":"Coeliac disease","volume":"399","author":"Catassi C","year":"2022","journal-title":"Lancet"},{"issue":"1","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/MPG.0000000000002497","article-title":"European Society Paediatric 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