{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T08:02:58Z","timestamp":1784793778718,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK078392"],"award-info":[{"award-number":["P30 DK078392"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n Pediatric acute pancreatitis (AP), Crohn's disease (CD), and irritable bowel syndrome (IBS) are associated with gut dysbiosis, but differences and similarities between conditions are unknown. We hypothesized that gut microbial ecology would differ across these disorders.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Stool was collected from 120 subjects (AP [\n n<\/jats:italic>\n \u2009=\u200930], CD [\n n<\/jats:italic>\n \u2009=\u200929], IBS Rome IV [\n n<\/jats:italic>\n \u2009=\u200927], and healthy controls [HC,\n n<\/jats:italic>\n \u2009=\u200934]). Shotgun metagenomic sequencing was performed on extracted DNA and taxonomic and functional profiles obtained using sylph and HUMAnN3 with default parameters.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Age interquartile range for all participants was 8.1\u201317.7 years. Shannon diversity was decreased in AP compared to IBS or HC (\n p<\/jats:italic>\n \u2009<\u20090.0001) and similar to CD (\n p<\/jats:italic>\n \u2009=\u20090.97). CD differed from IBS (\n p<\/jats:italic>\n \u2009=\u20090.001) and HC (\n p<\/jats:italic>\n \u2009<\u20090.0001) while IBS and HC were similar (\n p<\/jats:italic>\n \u2009=\u20090.61). Ordination of the first two principal coordinate analyses axes showed sample clustering by condition (\n R<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090.12,\n p<\/jats:italic>\n \u2009<\u20090.001), and differences between all conditions in pairwise comparisons (\n p<\/jats:italic>\n \u2009<\u20090.001).\n Escherichia coli<\/jats:italic>\n ,\n Ruminococcus gnavus<\/jats:italic>\n ,\n Staphylococcus aureus,<\/jats:italic>\n and\n Thomasciavelia ramosa<\/jats:italic>\n remained enriched when all conditions (AP, CD, and IBS) were compared as a single group to HC. Using a random forest machine learning algorithm for species relative abundance, the ability to classify a sample to each condition versus all others was highest for CD (area under the receiver operative characteristic curve, AUC\u2009=\u20090.97), followed by AP (AUC\u2009=\u20090.92), HC (AUC\u2009=\u20090.88), and IBS (AUC\u2009=\u20090.83).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Organic disorders (AP and CD) are associated with significant gut dysbiosis than IBS which appears more like HC. Interventions targeting shifts in commensals in AP and CD may be helpful in improving outcomes in both disorders.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jpn3.70504","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:44:46Z","timestamp":1784022286000},"source":"Crossref","is-referenced-by-count":0,"title":["Gut microbiome in pediatric acute pancreatitis and Crohn's disease versus irritable bowel syndrome and healthy controls"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0896-079X","authenticated-orcid":false,"given":"Neha R.","family":"Santucci","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics, College of Medicine University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinenye R.","family":"Dike","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition The University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Hellmann","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics, College of Medicine University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ollberding","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine University of Cincinnati Cincinnati Ohio USA"},{"name":"Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Duan","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Minar","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics, College of Medicine University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee A.","family":"Denson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics, College of Medicine University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Haslam","sequence":"additional","affiliation":[{"name":"Infectious Diseases Cincinnati Children's Hospital Medical Cent Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Castillo","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology The Nemours Foundation Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisam","family":"Abu\u2010El\u2010Haija","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics, College of Medicine University of Cincinnati Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.11.002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-017-0454-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2018.04.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14573"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2023.10.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izac175"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00222-5"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.02.005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1237-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-304833"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30317-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.09.008"},{"issue":"8","key":"e_1_2_9_14_1","first-page":"1212","article-title":"Microbial 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