{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T10:07:53Z","timestamp":1784023673633,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Serology\u2010only diagnosis of celiac disease is increasing, but few recent studies have looked at the outcomes of patients undergoing this approach. The aim of this study was to evaluate difference in clinical follow\u2010up and decline in tissue transglutaminase immunoglobulin A (TTG IgA) for patients receiving serology\u2010only versus biopsy diagnosis of celiac disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with a TTG IgA at or above 10 times upper limit of normal between October 1, 2020 and September 30, 2022 and were subsequently diagnosed with celiac disease with or without biopsy and had ongoing follow\u2010up at Seattle Children's Hospital for 2 years after diagnosis were included. The patient's symptoms at diagnosis and follow\u2010up visits, number of gastroenterology (GI) visits, timing of GI visits, number of dietician visits and timing of dietitian visits were documented. TTG IgA titers, human leukocyte antigen (HLA) antibody status, and esophagogastroduodenoscopy results were recorded. The data were analyzed using Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test or the Wilcoxon rank\u2010sum test as appropriate. Differences in categorical variables were assessed with chi\u2010square.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010four patients were included. The mean age at diagnosis was 9.7\u2009\u00b1\u20094.3 years. Diagnosis was by biopsy in 32 (59%) patients and serology\u2010only in 22 (41%) patients. The TTG IgA titers were similar at study baseline and decreased in both the biopsy and serology\u2010only diagnostic groups. The\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value at all time points were not significant. The mean time to first dietitian visit, mean number of dietitian visits, and mean number of dietitian visits in the 24 months of follow\u2010up was not significantly different between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serology\u2010only diagnosis resulted in a similar rate of clinical follow\u2010up and TTG IgA reduction when compared to biopsy diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70506","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:46:21Z","timestamp":1784022381000},"source":"Crossref","is-referenced-by-count":0,"title":["Does diagnosis by biopsy versus serology\u2010only affect follow\u2010up in celiac disease?"],"prefix":"10.1002","author":[{"given":"Maria Cristina","family":"Pacheco","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Kokesh","sequence":"additional","affiliation":[{"name":"University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Dickerson","sequence":"additional","affiliation":[{"name":"Department of Laboratories Seattle Children's Hospital  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Rompca","sequence":"additional","affiliation":[{"name":"Seattle Children's Hospital Division of Gastroenterology and Hepatology  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8148-3988","authenticated-orcid":false,"given":"Dale","family":"Lee","sequence":"additional","affiliation":[{"name":"Seattle Children's Hospital Division of Gastroenterology and Hepatology  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002075"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001216"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpr3.12087"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-024-05849-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2025-070897"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003923"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002323"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.05.046"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70506","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:46:22Z","timestamp":1784022382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":10,"alternative-id":["10.1002\/jpn3.70506"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70506","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]},"article-number":"jpn3.70506"}}