{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:07:09Z","timestamp":1785146829059,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The post\u2010reflux swallow\u2010induced peristaltic wave (PSPW) reflects esophageal chemical clearance. Pediatric data on this parameter remain limited. The aim of this study was to evaluate the behavior of the PSPW in children of different ages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of pediatric multichannel intraluminal pH\/impedance, studies were performed for suspected gastroesophageal reflux (GER). We included those with a normal reflux index, symptom index &lt;50%, symptom association probability &lt;95% and a number of reflux episodes within normal parameters for age. Patients were divided into three groups according to their age: Group I (0\u2013\u22642 years), Group II (&gt;2\u2013\u226410 years), and Group III (&gt;10\u2013\u226418 years). The PSPW index was calculated manually.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two hundred and sixty\u2010one studies were analyzed, 195 were included (median age 6.3 years, 54% female). Group I showed significantly more reflux events (38 vs. 26 and 32 in Groups II\u2013III,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) with predominance of non\u2010acid reflux (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and greater proximal extent (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). PSPW index was significantly lower in Group I (42.1%) compared to Groups II (52.6%) and III (50.0%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this pediatric cohort, a higher number of gastroesophageal reflux episodes, a predominance of non\u2010acid reflux and greater proximal extent were observed in infants \u22642 years, as well as reduced chemical clearance, which is reflected in a lower PSPW index compared to the other groups analyzed. Age\u2010specific interpretation of PSPW could improve the evaluation of pediatric GER and therapeutic management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70511","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T09:35:37Z","timestamp":1785144937000},"source":"Crossref","is-referenced-by-count":0,"title":["Are there age\u2010related differences in the frequency of post\u2010reflux peristaltic waves during impedance\u2010pH monitoring?"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1656-0781","authenticated-orcid":false,"given":"Judith","family":"Cohen Sabban","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4922-836X","authenticated-orcid":false,"given":"Jhoanna Valery","family":"Adauto Luizaga","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6744-9599","authenticated-orcid":false,"given":"Florencia Grisel","family":"Ursino","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3272-5059","authenticated-orcid":false,"given":"Maria Paula","family":"Manin","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0309-2660","authenticated-orcid":false,"given":"Vanina Laura","family":"Pagotto","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3015-0598","authenticated-orcid":false,"given":"Veronica","family":"Busoni","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-0254","authenticated-orcid":false,"given":"Marina","family":"Orsi","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/MPG.0000000000001889","article-title":"Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition","volume":"66","author":"Rosen R","year":"2018","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/01.JAA.0000731488.99461.39","article-title":"Understanding gastroesophageal reflux disease in children","volume":"34","author":"Friedman C","year":"2021","journal-title":"JAAPA"},{"issue":"11","key":"e_1_2_7_4_1","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13113351","article-title":"The utility of novel pH\u2010impedance monitoring parameters (PSPW index and MNBI) in pediatric gastroesophageal reflux disease phenotypes: a systematic review","volume":"13","author":"Pop RS","year":"2024","journal-title":"J Clin Med"},{"issue":"1","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cgh.2015.06.026","article-title":"Analyses of the post\u2010reflux swallow\u2010induced peristaltic wave index and nocturnal baseline impedance parameters increase the diagnostic yield of impedance\u2010pH monitoring of patients with reflux disease","volume":"14","author":"Frazzoni M","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/nmo.12080","article-title":"Esophageal chemical clearance is impaired in gastro\u2010esophageal reflux disease: a 24\u2010h impedance\u2010pH monitoring assessment","volume":"25","author":"Frazzoni M","year":"2013","journal-title":"Neurogastroenterol Motility"},{"issue":"11","key":"e_1_2_7_7_1","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13116","article-title":"Postreflux swallow\u2010induced peristaltic wave index and nocturnal baseline impedance can link PPI\u2010responsive heartburn to reflux better than acid exposure time","volume":"29","author":"Frazzoni L","year":"2017","journal-title":"Neurogastroenterol Motility"},{"issue":"8","key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1007\/s10620-017-4625-8","article-title":"Impedance\u2010pH monitoring for diagnosis of reflux disease: new perspectives","volume":"62","author":"Frazzoni M","year":"2017","journal-title":"Dig Dis Sci"},{"issue":"3","key":"e_1_2_7_9_1","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12030940","article-title":"Novel impedance\u2010pH parameters in pre\u2010bariatric assessment of patients: a pilot study","volume":"12","author":"Gagliardi M","year":"2023","journal-title":"J Clin Med"},{"issue":"8","key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/dote.12152","article-title":"Behind the impedance baseline in children","volume":"27","author":"Salvatore S","year":"2014","journal-title":"Dis Esophagus"},{"issue":"2","key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/MPG.0b013e3181ffde67","article-title":"Esophageal impedance monitoring for gastroesophageal reflux","volume":"52","author":"Mousa HM","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70511","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T09:35:39Z","timestamp":1785144939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":10,"alternative-id":["10.1002\/jpn3.70511"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70511","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"article-number":"jpn3.70511"}}