{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:34:21Z","timestamp":1786365261968,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Identifying predictors of poor outcomes (POPO) in paediatric Crohn's disease (CD) may guide therapy. We assessed predictors of 2\u2010year non\u2010remission (primary outcome) and time to first remission (TFR), corticosteroid\u2010free remission (TCSFR, \u22653 months corticosteroid (CS) withdrawal and sustained remission (TSR, \u22656 months) (secondary outcomes) in paediatric CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analysed prospectively collected data from 6959 paediatric CD patients (&lt;18 years; 2007\u20132023) in the ImproveCareNow Registry. Remission was defined as a short Paediatric CD Activity Index &lt;10. Logistic and Cox regression (\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.05), using R 4.5.0 with multiple imputation, identified predictors for both outcomes (at 0, 1, 5, 6, 12, and 24 months).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For the primary outcome, 53\/794 patients (6.7%) failed to achieve remission during 2\u2010year follow\u2010up. Female sex (odds ratio [OR]\u2009=\u20093.12, 95% confidence interval [CI] 1.48\u20136.55) and need for ustekinumab after 1 year (OR\u2009=\u200914.70, 95% CI 4.37\u201349.46) predicted non\u2010remission. For the secondary outcomes (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093290), mean TFR, TCSFR and TSR were 4.5, 16.4, and 8.2 months, respectively. Longer TFR was predicted by female sex (hazard ratio [HR]\u2009=\u20090.81, 95% CI 0.71\u20130.92) and the need for infliximab (IFX, HR\u2009=\u20091.15, 95% CI 1.00\u20131.32) at first visit. Longer TCSFR was associated with female sex (HR\u2009=\u20090.85, 95% CI 0.78\u20130.93), race (white HR\u2009=\u20090.83, 95% CI 0.74\u20130.93 and Asian HR\u2009=\u20091.42, 95% CI 1.05\u20131.92) and type of treatment at first visit (faster if IFX, slower if CS or immunomodulators). For TSR, predictors included age at diagnosis (HR\u2009=\u20091.06, 95% CI 1.02\u20131.11) and body mass index (BMI) (HR\u2009=\u20090.97, 95% CI 0.94\u20131.00).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinical parameters (female sex, younger age, and higher BMI) and therapeutic strategy (early\/late use of biologicals) are POPO and associated with longer time to remission in paediatric CD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70519","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T21:09:10Z","timestamp":1785272950000},"source":"Crossref","is-referenced-by-count":0,"title":["The ImproveCareNow Registry: Prediction of remission rates in paediatric Crohn's disease"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4519-0245","authenticated-orcid":false,"given":"Jonathan","family":"Van Hecke","sequence":"first","affiliation":[{"name":"Geneeskunde en Farmacie Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2701-9564","authenticated-orcid":false,"given":"Gigi","family":"Veereman","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology, Hepatology and Nutrition Universitair Ziekenhuis Brussel \u2010 Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6402-1762","authenticated-orcid":false,"given":"Koen","family":"Huysentruyt","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology, Hepatology and Nutrition Universitair Ziekenhuis Brussel \u2010 Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8431-1556","authenticated-orcid":false,"given":"Bruno","family":"Hauser","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology, Hepatology and Nutrition Universitair Ziekenhuis Brussel \u2010 Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3458-0336","authenticated-orcid":false,"given":"Wilfried","family":"Cools","sequence":"additional","affiliation":[{"name":"Support for Quantitative and Qualitative Research (SQUARE) Core Facility Universitair Ziekenhuis Brussel \u2010 Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5014-7878","authenticated-orcid":false,"given":"Niels F.","family":"Cleymans","sequence":"additional","affiliation":[{"name":"Research Centre for Digital Medicine (REDM) Vrije Universiteit Brussel Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-6098","authenticated-orcid":false,"given":"Jeremy","family":"Adler","sequence":"additional","affiliation":[{"name":"Susan B. Meister Child Health Evaluation and Research Center University of Michigan Ann Arbor Michigan USA"},{"name":"Division of Paediatric Gastroenterology, Michigan Medicine Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-7891","authenticated-orcid":false,"given":"Shehzad","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Boonshoft School of Medicine Wright State University Dayton Children's Hospital Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"De Greef","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology, Hepatology and Nutrition Universitair Ziekenhuis Brussel \u2010 Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ImproveCareNow Paediatric IBD Learning Health System","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.07.065"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.031"},{"issue":"2","key":"e_1_2_9_4_1","article-title":"The medical management of paediatric Crohn's disease: an ECCO\u2010ESPGHAN guideline update","volume":"15","author":"Rheenen PF","year":"2021","journal-title":"J Crohns Colitis"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21493"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21394"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21452"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21649"},{"key":"e_1_2_9_9_1","unstructured":"Centers for Disease Control Prevention. 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