{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T07:20:18Z","timestamp":1784791218259,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the clinical characteristics, diagnostic modalities, and age\u2010related variation of Meckel's diverticulum (MD) using data from a nationwide pediatric inpatient database and a single\u2010center institutional cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Kids' Inpatient Database (KID) for 2016 and 2019 was queried for patients with a principal diagnosis of MD. We additionally conducted a retrospective review of patients hospitalized with a primary diagnosis of MD at our institution over a 20\u2010year period (January 1, 2005\u2013May 1, 2025). Diagnosis was confirmed by surgical findings and pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1004 patients with a primary diagnosis of MD were identified in KID. More than half were diagnosed after 5 years of age (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009648, 64.8%). Similarly, among 147 patients identified in the single\u2010center cohort, 63.2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200993) were diagnosed after 5 years of age. Within this single\u2010center cohort, patients \u22645 years more commonly presented with painless rectal bleeding (38.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017) and underwent Meckel's scintigraphy more frequently (48.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.005). In contrast, patients &gt;5 years more often presented with abdominal pain (61.3%) or vomiting (54.8%) and were more likely to undergo abdominal computed tomography (68.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Length of stay (LOS) was longer in patients &lt;5 years and shortest in those &gt;15 years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>More than half of pediatric patients with MD are diagnosed after 5 years of age. Presentation, LOS, and imaging patterns vary by age, with younger children more often presenting with bleeding and older children with obstructive symptoms and greater CT detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70521","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:58:05Z","timestamp":1784789885000},"source":"Crossref","is-referenced-by-count":0,"title":["Reevaluating the rule of two's: Age and epidemiological variations in Meckel's diverticulum"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9062-920X","authenticated-orcid":false,"given":"Ashley","family":"Polachek","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology UT Southwestern Medical Center Dallas Texas USA"},{"name":"Children's Health Children's Medical Center Dallas Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megha S.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology UT Southwestern Medical Center Dallas Texas USA"},{"name":"Children's Health Children's Medical Center Dallas Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Shalaby","sequence":"additional","affiliation":[{"name":"Lyda Hill Department of Bioinformatics UT Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamirah","family":"Vadsariya","sequence":"additional","affiliation":[{"name":"Informatics Coordinating Office University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zong","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology UT Southwestern Medical Center Dallas Texas USA"},{"name":"Children's Health Children's Medical Center Dallas Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Troendle","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology UT Southwestern Medical Center Dallas Texas USA"},{"name":"Children's Health Children's Medical Center Dallas Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"issue":"35","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000012154","article-title":"Systematic review of epidemiology, presentation, and management of Meckel's diverticulum in the 21st century","volume":"97","author":"Hansen CC","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/01.sla.0000154270.14308.5f","article-title":"Meckel diverticulum: the Mayo Clinic experience with 1476 patients (1950\u20132002)","volume":"241","author":"Park JJ","year":"2005","journal-title":"Ann Surg"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00383-014-3513-y","article-title":"Demographic disparities of children presenting with symptomatic Meckel's diverticulum in children's hospitals","volume":"30","author":"Alemayehu H","year":"2014","journal-title":"Pediatr Surg Int"},{"issue":"5","key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jpedsurg.2011.02.024","article-title":"National trends in the surgical management of Meckel's diverticulum","volume":"46","author":"Ruscher K","year":"2011","journal-title":"J Pediatr Surg"},{"issue":"2","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1148\/rg.242035187","article-title":"From the archives of the AFIP. Meckel diverticulum: radiologic features with pathologic correlation","volume":"24","author":"Levy AD","year":"2004","journal-title":"Radiographics"},{"issue":"3","key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2967\/jnmt.113.136242","article-title":"SNMMI and EANM practice guideline for meckel diverticulum scintigraphy 2.0","volume":"42","author":"Spottswood SE","year":"2014","journal-title":"J Nucl Med Technol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00383-007-2094-4","article-title":"Symptomatic Meckel's diverticulum in children: a 16\u2010year review","volume":"24","author":"Menezes M","year":"2008","journal-title":"Pediatr Surg Int"},{"issue":"11","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/0022-3468(91)90601-O","article-title":"Meckel's diverticulum in children: a 20\u2010year review","volume":"26","author":"St\u2010Vil D","year":"1991","journal-title":"J Pediatr Surg"},{"issue":"32","key":"e_1_2_8_10_1","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000007760","article-title":"Clinical characteristics of Meckel diverticulum in children: a retrospective review of a 15\u2010year single\u2010center experience","volume":"96","author":"Lin X","year":"2017","journal-title":"Medicine"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jpedsurg.2017.11.059","article-title":"Multifaceted behavior of Meckel's diverticulum in children","volume":"53","author":"Chen Q","year":"2018","journal-title":"J Pediatr Surg"},{"issue":"10","key":"e_1_2_8_12_1","doi-asserted-by":"crossref","DOI":"10.3390\/jcm15103599","article-title":"Clinical and anatomical spectrum of Meckel's diverticulum: a systematic review and meta\u2010analysis","volume":"15","author":"Plutecki D","year":"2026","journal-title":"J Clin Med"},{"issue":"2","key":"e_1_2_8_13_1","article-title":"Health equity and policy considerations for pediatric and adult congenital heart disease care among minoritized populations in the United States","volume":"11","author":"Lopez KN","year":"2024","journal-title":"J Cardiovasc Dev Dis"},{"issue":"7","key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00247-008-1138-9","article-title":"CT findings in children with Meckel diverticulum","volume":"39","author":"Olson DE","year":"2009","journal-title":"Pediatr Radiol"},{"issue":"2","key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2214\/AJR.14.13898","article-title":"CT detection of symptomatic and asymptomatic Meckel diverticulum","volume":"205","author":"Kawamoto S","year":"2015","journal-title":"Am J Roentgenol"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70521","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70521","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:58:07Z","timestamp":1784789887000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":14,"alternative-id":["10.1002\/jpn3.70521"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70521","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"article-number":"jpn3.70521"}}