{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:44:54Z","timestamp":1793897094185,"version":"4.8.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Oesophageal stenosis is a serious sequel of caustic ingestion, especially refractory caustic oesophageal strictures (COS) with a high risk of adverse events and variable response to treatments such as dilations, infiltration of substances and stent placement. Platelet\u2010rich plasma (PRP) has been used in various pathologies that require a process of repair and healing of tissues at the skin, mucosa and joints. We aimed to describe the experience managing refractory COS in children with endoscopic\u2010guided PRP intralesional administration, in terms of practicability of the procedure, efficacy and safety in the first prospective series in Venezuela.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children with refractory COS, with a length of evolution between 7 months to 3 years, and previous treatment attempts (steroids, Mitomycin C or stent placement), underwent endoscopic\u2010guided PRP intralesional administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen patients were included. After only one PRP administration session, 15\/16 (93.8%) patients had improvement in dysphagia, in solid food tolerance and an increase in body weight. Only 4\/16 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) requested a second infiltration session. One patient was withdrawn from the follow\u2010up by the tutor. During the first 6\u2010month follow\u2010up, 15\/15 patients, (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) presented without dysphagia. There was no adverse event related to the dilation or PRP administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The excellent response after endoscopic\u2010guided PRP intralesional administration represents an effective and safe alternative for refractory COS children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70532","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:45:53Z","timestamp":1786967153000},"page":"888-897","source":"Crossref","is-referenced-by-count":1,"title":["Endoscopic\u2010guided platelet\u2010rich plasma for refractory oesophageal strictures in children: A single\u2010arm cohort study"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1378-7995","authenticated-orcid":false,"given":"Ileana","family":"Gonz\u00e1lez\u2010Natale","sequence":"first","affiliation":[{"name":"Departament of Pediatric Gastroenterology Hospital de Ni\u00f1os Jos\u00e9 Manuel De Los R\u00edos Caracas Venezuela"},{"name":"Hospital de Cl\u00ednicas Caracas Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daysmar","family":"Salazar","sequence":"additional","affiliation":[{"name":"Departament of Pediatric Gastroenterology Hospital de Ni\u00f1os Jos\u00e9 Manuel De Los R\u00edos Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maylin","family":"Davila","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Sanatrix  Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurihelis","family":"Saveri","sequence":"additional","affiliation":[{"name":"Departament of Pediatric Gastroenterology Hospital de Ni\u00f1os Jos\u00e9 Manuel De Los R\u00edos Caracas Venezuela"},{"name":"Hospital de Cl\u00ednicas Caracas Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eugenia","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Departament of Pediatric Gastroenterology Hospital de Ni\u00f1os Jos\u00e9 Manuel De Los R\u00edos Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Puga\u2010Tejada","sequence":"additional","affiliation":[{"name":"Instituto Ecuatoriano de Enfermedades Digestivas (IECED) Guayaquil Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Baptista","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas Caracas Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"126","article-title":"Zargar classification: ingestion of caustics","volume":"27","author":"Araya R","year":"2016","journal-title":"Gastroenterol Latinoam"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/dox029"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11938-014-0043-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2005.04.050"},{"issue":"4","key":"e_1_2_7_6_1","first-page":"248","article-title":"Topical Mitomycin C versus intralesional triamcinolone in the management of esophageal stricture due to caustic ingestion","volume":"80","author":"Mendez\u2010Nieto C","year":"2015","journal-title":"Rev Gastroenterol Mex"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.101B8.BJJ-2019-0037.R1"},{"key":"e_1_2_7_8_1","first-page":"1","article-title":"Platelet\u2010rich plasma in the healing of soft tissues of the oral cavity","volume":"4","author":"Garay A","year":"2014","journal-title":"Acta Bioclin. 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