{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:24:29Z","timestamp":1787646269942,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Hypertransaminasemia is a frequent finding in hospitalized children with common pediatric illnesses, often considered a transitory phenomenon associated with systemic inflammation\/injury. This study aims to assess the prevalence and causes of incidentally detected hypertransaminasemia in children admitted to general pediatric units for non\u2010chronic liver\u2010related illnesses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a prospective, multicenter observational study. Children with transaminase measurement at hospital admission were enrolled from June 2021 to July 2023. Inclusion criteria were: Age &gt;30 days to 17 years; hospitalization for any clinical condition; Informed consent. Patients with a previous diagnosis of liver disease were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1652 patients (1 month to 17 years) were enrolled in nine Italian pediatric hospital centers. Overall, the prevalence of hypertransaminasemia was 34.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009570). The majority had mild to moderate liver enzymes elevation. Positive correlation were found between aspartate aminotransferase and creatin P\u2010kinase (CPK), body mass index\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score and cholesterol. At discharge, 298 of the 570 re\u2010tested transaminases: 21.4% (64\/298) had persistent combined elevation, 13.8% (41\/298) isolated alanine aminotransferase, and 37.6% (112\/298) isolated elevation. Only 5.70% of the patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) with elevated transaminase levels (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009526) were eventually diagnosed with liver disease at discharge, whereas the majority of patients (19.9%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009105) received a diagnosis of pneumonia\/bronchitis\/upper respiratory tract infection, followed by unspecified infections (10.6%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200956).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hypertransaminasemia is common in children admitted to the general pediatric units, affecting approximately 35% of patients. Liver\u2010related discharge diagnoses were uncommon among children with elevated transaminases (5.70%), whereas most cases occurred in the setting of acute non\u2010hepatic illnesses. Children with persistently elevated transaminases at discharge should be followed to rule out chronic liver disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70540","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:41:18Z","timestamp":1787118078000},"source":"Crossref","is-referenced-by-count":0,"title":["Hypertransaminasemia in hospitalized children: Insights from a national multicenter study by the Italian Society of Pediatric Gastroenterology, Hepatology, and Nutrition"],"prefix":"10.1002","author":[{"given":"Angelo","family":"Di Giorgio","sequence":"first","affiliation":[{"name":"Paediatric Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII University of Udine Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giusy","family":"Ranucci","sequence":"additional","affiliation":[{"name":"Pediatric Department IRCCS ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione) Palermo Italy"},{"name":"UPMC (University of Pittsburgh Medical Center) Italy Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3258-2769","authenticated-orcid":false,"given":"Pietro","family":"Aliberti","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science, Section of Pediatrics University of Naples \u201cFederico II\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela Pia","family":"Senatore","sequence":"additional","affiliation":[{"name":"University of Salerno Fisciano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Cal\u00ec","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Santobono\u2010Pausilipon Pediatric Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Mazza","sequence":"additional","affiliation":[{"name":"General Paediatric Department Hospital Papa Giovanni XXIII Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Sbravati","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Maggiore Hospital Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Alvisi","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Maggiore Hospital Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio Giuseppe","family":"Fuoti","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Endoscopy Unit, University Department of Pediatrics, Children's Hospital Spedali Civili Brescia 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