{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:10:32Z","timestamp":1788775832228,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated the associations between dietary behaviors and gut microbiota in children with autism spectrum disorder (ASD) stratified according to symptom severity, aiming to provide evidence for targeted interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional study enrolled 81 children with ASD aged 3\u201312 years, divided into mild\u2010to\u2010moderate (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935) and severe (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200946) groups based on Childhood Autism Rating Scale scores. Dietary behaviors were assessed using the Children's Eating Behavior Questionnaire. Gut microbiota was analyzed by 16S rRNA (16S ribosomal RNA)\u00a0gene sequencing. Spearman correlation examined associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The severe ASD group showed significantly lower Enjoyment of Food scores and higher scores for both Emotional Undereating and Emotional Overeating (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Alpha diversity (Shannon and Simpson indices) was significantly lower in the severe group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Beta diversity showed significant between\u2010group separation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The severe group exhibited decreased\n                      <jats:italic>Firmicutes<\/jats:italic>\n                      and increased\n                      <jats:italic>Proteobacteria<\/jats:italic>\n                      at the phylum level, with decreased\n                      <jats:italic>Faecalibacterium<\/jats:italic>\n                      and\n                      <jats:italic>Dialister<\/jats:italic>\n                      and a 2.8\u2010fold increase in\n                      <jats:italic>Klebsiella<\/jats:italic>\n                      at the genus level (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Correlation analysis revealed severity\u2010dependent associations: mild\u2010to\u2010moderate ASD showed phylum\u2010level associations, while severe ASD showed genus\u2010level associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Children with severe ASD exhibited more pronounced dietary behavior abnormalities and gut microbiota dysbiosis. The severity\u2010dependent associations suggest stratified intervention strategies for ASD children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70552","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T07:14:46Z","timestamp":1788160486000},"source":"Crossref","is-referenced-by-count":0,"title":["The correlation between dietary behaviors and gut microbiota in children with autism spectrum disorder: A cross\u2010sectional study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4109-1637","authenticated-orcid":false,"given":"Aliye","family":"Aili","sequence":"first","affiliation":[{"name":"Department of Child and Maternal Health, School of Public Health Xinjiang Medical University Urumqi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zumureti","family":"Yimin","sequence":"additional","affiliation":[{"name":"Department of Child Health Care The First Affiliated Hospital of Xinjiang Medical University Urumqi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadire","family":"Maiming","sequence":"additional","affiliation":[{"name":"Urumqi Center for Disease Control and Prevention (Municipal Health Supervision Institute) Urumqi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilijiang","family":"Tuhongjiang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine\uff0cXinjiang Uygur Autonomous Region Children's Hospital Urumqi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazila","family":"Paerhati","sequence":"additional","affiliation":[{"name":"Yining City Center for Disease Control and Prevention (Health Supervision Institute) Yining People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xayida","family":"Aini","sequence":"additional","affiliation":[{"name":"Department of Child and Maternal Health, School of Public Health Xinjiang Medical University Urumqi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asimuguli","family":"Kelimu","sequence":"additional","affiliation":[{"name":"Department of Child and Maternal Health, School of Public Health Xinjiang Medical University Urumqi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rena","family":"Maimaiti","sequence":"additional","affiliation":[{"name":"Department of Child Health Care The First Affiliated Hospital of Xinjiang Medical University Urumqi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"issue":"14","key":"e_1_2_9_2_1","first-page":"169","article-title":"Research progress on the correlation between gut microbiota and autism spectrum disorder in children","volume":"20","author":"Ling J","year":"2023","journal-title":"Chin Med Innov"},{"issue":"8","key":"e_1_2_9_3_1","first-page":"625","article-title":"Research progress on bumetanide in the treatment of children with autism spectrum disorder","volume":"39","author":"Duan CL","year":"2024","journal-title":"Chin J Pract Clin Pediatr"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2696"},{"key":"e_1_2_9_5_1","unstructured":"Cai KL.Effects of Small Basketball Exercise on Social Impairment and White Matter Integrity in Preschool Children With Autism Spectrum Disorder. 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