{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:11:10Z","timestamp":1788775870123,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Necrotizing enterocolitis (NEC) remains a major cause of morbidity and mortality in very low birth weight infants, while the safest rate of enteral feed advancement remains debated. We performed a retrospective single\u2010center before\u2010after cohort study in a tertiary neonatal intensive care unit, comparing two feeding strategies in 572 infants (286 per group): faster advancement (20\u201330 mL\/kg\/day) from 2015\u20132018 and slower advancement (10\u201325 mL\/kg every 48 h, weight\u2010dependent) from 2020\u20132023. The primary outcome was NEC, defined as Bell stage \u2265IIb or diagnosis at surgery. NEC was less frequent in the slower\u2010advancement era (2.1% vs 7.9%; adjusted\n                    <jats:italic>p<\/jats:italic>\n                    = 0.02). Mortality, late\u2010onset sepsis, central venous catheter duration, and extrauterine growth restriction were similar. Faster advancement led to earlier full enteral feeding, while discharge weight centiles were comparable. A cautious feeding strategy was associated with lower NEC incidence without evidence of worse infectious or growth outcomes.\n                  <\/jats:p>","DOI":"10.1002\/jpn3.70559","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:31:36Z","timestamp":1788327096000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of a slow feeding advancement protocol on necrotizing enterocolitis incidence in preterm infants: A before\u2010and\u2010after study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-7220","authenticated-orcid":false,"given":"Samuele","family":"Caruggi","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Maternal and Neonatal Health IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2710-1798","authenticated-orcid":false,"given":"Andrea","family":"Calandrino","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Maternal and Neonatal Health IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3164-1906","authenticated-orcid":false,"given":"Marcella","family":"Battaglini","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Maternal and Neonatal Health IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Baudi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother\/Child Sciences (DINOGMI) University of Genova Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Lionetti","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Maternal and Neonatal Health IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Mongelli","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Maternal and Neonatal Health IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3693-1555","authenticated-orcid":false,"given":"Francesco","family":"Vinci","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Maternal and Neonatal Health IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Massirio","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Maternal and Neonatal Health IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Parodi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Maternal and Neonatal Health IRCCS Istituto Giannina Gaslini Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca Antonio","family":"Ramenghi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Maternal and Neonatal Health IRCCS Istituto Giannina Gaslini Genoa Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother\/Child Sciences (DINOGMI) University of Genova Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-024-00626-w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02231-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40746-024-00297-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2022.07.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2023.04.005"},{"issue":"8","key":"e_1_2_9_7_1","article-title":"Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants","volume":"8","author":"Oddie SJ","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-025-02277-2"},{"issue":"9","key":"e_1_2_9_9_1","article-title":"Donor human milk for preventing 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A retrospective single\u2010center experience at Gaslini Children's Hospital","volume":"12","author":"Caruggi S","year":"2025","journal-title":"Children (Basel, Switzerland)"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.10.040"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16030449"},{"issue":"4","key":"e_1_2_9_21_1","article-title":"Interventions for patent ductus arteriosus (PDA) in preterm infants: an overview of cochrane systematic reviews","volume":"4","author":"Mitra S","year":"2023","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70559","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T09:44:52Z","timestamp":1788774292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":20,"alternative-id":["10.1002\/jpn3.70559"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70559","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"article-number":"jpn3.70559"}}