{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:59:10Z","timestamp":1791287950666,"version":"4.3.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Functional abdominal pain (FAP) and functional constipation (FC), are common in children and affect quality of life. Dysfunction of the microbiota\u2013gut\u2013brain axis may contribute to their pathophysiology, with growing interest in probiotic interventions.\n                      <jats:italic>Limosilactobacillus reuteri<\/jats:italic>\n                      (\n                      <jats:italic>L. reuteri<\/jats:italic>\n                      ) DSM 17938 has been widely studied, but its efficacy remains unclear. This systematic review and meta\u2010analysis aimed to evaluate the efficacy of\n                      <jats:italic>L. reuteri<\/jats:italic>\n                      DSM 17938 in pediatric FAP and FC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Randomized controlled trials (RCTs) published up to October 2025 were identified from major databases. Eligible studies included children diagnosed by Rome criteria and treated with\n                      <jats:italic>L. reuteri<\/jats:italic>\n                      DSM 17938 as a single strain. Primary outcomes were responder rates for FAP and normalization of stool frequency for FC, with abdominal pain frequency and intensity assessed as secondary outcomes for FAP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five RCTs, including 302 children with FAP, and five RCTs, including 276 children with FC, were analyzed. In FAP,\n                      <jats:italic>L. reuteri<\/jats:italic>\n                      DSM 17938 did not significantly improve responder rates (risk ratio [RR] 1.11, 95% confidence interval [CI] 0.83\u20131.47,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.49), abdominal pain frequency (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.91; 95% CI \u22120.42 to 0.38), or pain intensity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.14, 95% CI \u22121.07 to 0.15) compared with placebo in meta\u2010analysis. In FC, the pooled analysis showed no significant difference in stool frequency (RR 1.1, 95% CI 0.94\u20131.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.27).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In this systematic review and meta\u2010analysis,\n                      <jats:italic>L. reuteri<\/jats:italic>\n                      DSM 17938 did not demonstrate clinically significant benefits in pediatric FAP or FC. Further well\u2010powered, strain\u2010specific RCTs with standardized outcome measures are warranted to clarify its role.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70565","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:16:33Z","timestamp":1790748993000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>Limosilactobacillus reuteri<\/i>\n                    DSM 17938 in pediatric functional abdominal pain disorders and functional constipation: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6729-5630","authenticated-orcid":false,"given":"Giovanna","family":"Quatrale","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS) Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7247-0092","authenticated-orcid":false,"given":"Marco","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS) Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0217-8780","authenticated-orcid":false,"given":"Luigi","family":"Colecchia","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7448-8710","authenticated-orcid":false,"given":"Valentina","family":"Giorgio","sequence":"additional","affiliation":[{"name":"UOSD Spina Bifida e Altre Branche Specialistiche, Department of Woman and Child Health, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS Catholic University of Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4000-6004","authenticated-orcid":false,"given":"Maurizio","family":"Mennini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS) Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9838-1076","authenticated-orcid":false,"given":"Sara","family":"Sergio","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS) Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9578-5614","authenticated-orcid":false,"given":"Marco","family":"Graziani","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS) Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1016-8797","authenticated-orcid":false,"given":"Giorgia","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS) Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3086-0406","authenticated-orcid":false,"given":"Silvia","family":"Furio","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS) Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Tiberia","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS) Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9745-0726","authenticated-orcid":false,"given":"Giovanni","family":"Barbara","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-8773","authenticated-orcid":false,"given":"Giovanni","family":"Marasco","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-7758","authenticated-orcid":false,"given":"Giovanni","family":"Di Nardo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Mental Health and Sensory Organs (NESMOS) Sapienza University of Rome Rome Italy"},{"name":"Pediatric Gastroenterology and Endoscopy Unit, Department of Pediatric Specialties Santobono Pausilipon Children's Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_8_2_1","article-title":"Functional disorders: children and adolescents","author":"Hyams JS","year":"2016","journal-title":"Gastroenterology"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126982"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.12.010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-042320-014032"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.817100"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.03.015"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms14010023"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13030627"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.840245"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S250755"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02615.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(98)00090-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00124.2010"},{"key":"e_1_2_8_16_1","unstructured":"Handbook for DTA reviews. 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