{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:59:13Z","timestamp":1791287953855,"version":"4.3.0"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In Crohn's disease (CD), magnetic resonance enterography (MRE) is used to assess small bowel disease activity. Intestinal ultrasound (IUS) is a less invasive, cheaper and more easily accessible imaging modality in CD. This study assesses the diagnostic accuracy of IUS versus MRE and defines an optimal bowel wall thickness (BWT) cut\u2010off in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children with CD undergoing MRE as routine care had IUS within 7 days. MRE disease activity was assessed using the segmental grading system and compared to IUS BWT and IUS scores. The terminal ileum (TI), ileum and jejunum were analysed separately.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010eight paediatric CD patients (median age: 15 years; 49% female) were included. Based on MRE, 44 bowel segments had mild and 37 moderate\u2010severe disease activity. The area under the receiver operating characteristic of IUS BWT for disease activity in the TI was 0.91 (95% confidence interval [CI] 0.84\u20130.98) with an optimal cut\u2010off of 2.4\u2009mm, 0.80 (95% CI 0.66\u20130.94) for the ileum with an optimal cut\u2010off of 2.0\u2009mm (sensitivity 76%; specificity 93%) and 0.69 (95% CI 0.52\u20130.86) for the jejunum. Due to the low number of affected segments in the jejunum, an accurate BWT cut\u2010off value could not be determined. Previously developed IUS scores did not outperform BWT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IUS is an accurate tool to non\u2010invasively assess CD activity in the TI and ileum. Based on our results, a BWT cut\u2010off of 2.4\u2009mm in the TI and 2.0\u2009mm in the ileum in paediatric CD is optimal to distinguish active from inactive disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70580","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:36:06Z","timestamp":1790750166000},"source":"Crossref","is-referenced-by-count":0,"title":["Intestinal ultrasound versus magnetic resonance enterography for detecting small bowel Crohn's disease in children"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8166-7022","authenticated-orcid":false,"given":"Johanna M. B. W.","family":"Vos","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology and Nutrition Amsterdam University Medical Centre, Emma Children's Hospital Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Research Institute Amsterdam University Medical Centre Amsterdam the Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute Amsterdam University Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa A. van","family":"Wassenaer","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology and Nutrition Amsterdam University Medical Centre, Emma Children's Hospital Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1647-5152","authenticated-orcid":false,"given":"Anouk J.","family":"Konert","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology and Nutrition Amsterdam University Medical Centre, Emma Children's Hospital Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4982-6615","authenticated-orcid":false,"given":"Joost van","family":"Schuppen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Amsterdam University Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8876-6515","authenticated-orcid":false,"given":"Rick R. van","family":"Rijn","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Amsterdam University Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim G.J. de","family":"Meij","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology and Nutrition Amsterdam University Medical Centre, Emma Children's Hospital Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5822-4371","authenticated-orcid":false,"given":"Johan E.","family":"van Limbergen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology and Nutrition Amsterdam University Medical Centre, Emma Children's Hospital Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina B.","family":"Gecse","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert R. 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