{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:01:30Z","timestamp":1789988490848,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically evaluate the impact of early enteral nutrition (EEN) on children with acute pancreatitis (AP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomized controlled trials (RCTs) and quasi\u2010experimental studies investigating the effects of EEN on children with AP were retrieved from databases including China National Knowledge Infrastructure (CNKI), Wanfang, Chinese Scientific Journal Database (VIP), Chinese Biomedical Literature Database (CBM), PubMed, Cochrane Library, Embase, and Web of Science from inception to October 1, 2025. Data analysis was performed using RevMan 5.2 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine trials involving 485 children with AP were included. The analysis revealed that the observation group (EEN) demonstrated significant improvements compared to the control group in the following outcomes: serum albumin (standardized mean difference [SMD]\u2009=\u20091.28, 95% confidence interval [CI]\u2009=\u20090.68\u20131.88,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), acute physiology and chronic health evaluation II (APACHE\u2010II) score (SMD\u2009=\u2009\u22122.58, 95% CI\u2009=\u2009\u22124.46 to \u22120.70,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) level (SMD\u2009=\u2009\u22122.23, 95% CI\u2009=\u2009\u22123.36 to \u22121.10,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001), and incidence of adverse events (odds ratio [OR]\u2009=\u20090.30, 95% CI\u2009=\u20090.17\u20130.52,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EEN significantly increases serum albumin levels, reduces APACHE\u2010II scores and TNF\u2010\u03b1 levels, and decreases the incidence of adverse events in children with AP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70581","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:45:03Z","timestamp":1789436703000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of early enteral nutrition on children with acute pancreatitis: A systematic review and meta analysis"],"prefix":"10.1002","author":[{"given":"Lufang","family":"Rao","sequence":"first","affiliation":[{"name":"Department of General Surgery\/Hepatobiliary Surgery Center, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of General Surgery\/Hepatobiliary Surgery Center, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beili","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of General Surgery\/Hepatobiliary Surgery Center, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7354-3749","authenticated-orcid":false,"given":"Yingying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Research Ward, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9485-1268","authenticated-orcid":false,"given":"Yan","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of General Surgery\/Hepatobiliary Surgery Center, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents\u2019 Health and Diseases Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.20317"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3928\/19382359-20210713-01"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2020.100839"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01766-4"},{"issue":"2","key":"e_1_2_8_6_1","first-page":"253","article-title":"Glutamine supported early enteral therapy for severe acute pancreatitis: a systematic review and meta\u2010analysis","volume":"29","author":"Jiang X","year":"2020","journal-title":"Asia Pac J Clin Nutr"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4665-0"},{"issue":"1","key":"e_1_2_8_8_1","first-page":"7","article-title":"Guidelines for the diagnosis and treatment of acute pancreatitis","volume":"37","author":"Wang C","journal-title":"Zhejiang Med J"},{"key":"e_1_2_8_9_1","unstructured":"HigginsJPT GreenS.Cochrane Handbook for Systematic Reviews of Intervention Version 5.1.0 [Updated March 2011] [EB\/OL]. 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