{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:01:42Z","timestamp":1790661702719,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 82570601"],"award-info":[{"award-number":["NSFC 82570601"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 82370525"],"award-info":[{"award-number":["NSFC 82370525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 82470541"],"award-info":[{"award-number":["NSFC 82470541"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate health\u2010related quality of life (HRQoL) and identify associated factors in Chinese children with pediatric intestinal pseudo\u2010obstruction (PIPO) and their caregivers, while assessing caregiving burden and depression levels, and comparing the mother\u2013father dyads.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional, questionnaire\u2010based survey was completed by 68 caregivers from 46 patient families. Multidimensional assessments included: Pediatric Quality of Life Inventory\u2122 4.0 Generic Core Scales (PedsQL\u2122 4.0 GCM) for children; PedsQL\u2122 3.0 Family Impact Module (FIM) for caregivers; Zarit Caregiver Burden Interview (ZBI) and Patient Health Questionnaire\u20109 (PHQ\u20109) for depression. Two\u2010sample\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests or one\u2010way analysis of variance were used to compare average scores across subgroups. Intercorrelations were examined using Spearman's rank correlation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with healthy controls, children with PIPO and caregivers showed significantly worse HRQoL across all domains (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Recent hospitalization and higher treatment costs significantly lowered overall HRQoL scores both in children and caregivers (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Children's HRQoL was also associated with body mass index (BMI)\u2010for\u2010age\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score (BMI\u2010Z) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Higher financial burden and lower BMI\u2010Z were also linked to increased parental care burden and depression scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Additionally, children's HRQoL positively correlated with caregivers\u2019 HRQoL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). HRQoL negatively correlated with caregiving burden and depression scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Fathers reported lower caregiving burden, but higher depression scores compared with mothers (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study quantifies the burden of PIPO, demonstrating significant HRQoL impairment in both children and caregivers, as well as notable financial and psychosocial impacts on families. Future policies and guidelines should place greater emphasis on multidisciplinary care models to improve HRQoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70586","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:32:01Z","timestamp":1790155921000},"source":"Crossref","is-referenced-by-count":0,"title":["Proxy\u2010reported quality of life of children with intestinal pseudo\u2010obstruction and caregivers\u2019 self\u2010reported health outcomes in China"],"prefix":"10.1002","author":[{"given":"Chen","family":"Cai","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Shanghai Institute for Pediatric Research Shanghai China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5587-7772","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Shanghai Institute for Pediatric Research Shanghai China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaying","family":"You","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7791-7534","authenticated-orcid":false,"given":"Zhixuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landuoduo","family":"Du","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cai","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Shanghai Institute for Pediatric Research Shanghai China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition Shanghai China"},{"name":"Department of Pediatric Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0619-7580","authenticated-orcid":false,"given":"Guannan","family":"Bai","sequence":"additional","affiliation":[{"name":"Children's Hospital, Zhejiang University School of Medicine, National Children's Regional Medical Center National Clinical Research Center for Child Health Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2869-0264","authenticated-orcid":false,"given":"Weihui","family":"Yan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Shanghai Institute for Pediatric Research Shanghai China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14715"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001982"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003788"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13781"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001610-199202000-00005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2023.2193887"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003265"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-023-08066-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.275"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520902840806"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2025.114566"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-025-03682-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17050905"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12411"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1019644022606"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-019-0737-y"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-021-04365-9"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.837462"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.07.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-021-01805-w"},{"key":"e_1_2_9_22_1","unstructured":"National Bureau of Statistics.The Income and Consumption Expenditure of Residents in 2024. National Bureau of Statistics; 2024.https:\/\/www.stats.gov.cn\/sj\/zxfb\/202501\/t20250117_1958325.html"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15081944"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15030710"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(19)30407-9"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.5152\/TurkArchPediatr.2024.23126"},{"key":"e_1_2_9_27_1","first-page":"197","article-title":"Fathers\u2019 experiences of caring for a child with a chronic illness: a systematic review","volume":"10","author":"Spurr S","year":"2023","journal-title":"Children (Basel, Switzerland)"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.599039"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70586","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70586","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:35:12Z","timestamp":1790660112000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":27,"alternative-id":["10.1002\/jpn3.70586"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70586","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"article-number":"jpn3.70586"}}