{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:04:21Z","timestamp":1790661861400,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyse the serological immune response in paediatric patients with selective immunoglobulin A deficiency (SIgAD) and coeliac disease (CeD), focusing on immunoglobulin G antibody dynamics after starting the gluten\u2010free diet (GFD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from SIgAD patients with a CeD diagnosis, age less than 18 years, was retrospectively collected by the participating centres in this observational, multicentre, pan\u2010european registry, conducted by the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Coeliac Disease Special Interest group. The analysis of the dynamics of normalisation of different IgG antibodies was conducted using non\u2010parametric Kaplan\u2013Meier curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At diagnosis, there is no correlation between mucosal damage and serological levels and a small bowel biopsy is mandatory to confirm CeD in children with SIgAD. After starting a GFD IgG antibody levels decrease slowly in SIgAD patients with CeD, with 50% still serology positive after 3 years. It takes significantly longer for normalisation in those with IgG class anti\u2010transglutaminase antibodies (IgG\u2010TGA) baseline levels &gt;\u00d710 upper limit of normal (ULN). Early quantitative change in antibody levels was not predictive of final serological normalisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Decision\u2010making on invasive tests based exclusively on the follow\u2010up antibody results should be avoided, given that IgG\u2010class antibodies resolve much more slowly after commencing a GFD, especially in those patients with high baseline IgG\u2010TGA levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70589","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:15:43Z","timestamp":1790061343000},"source":"Crossref","is-referenced-by-count":0,"title":["Selective immunoglobulin A deficiency and coeliac disease: Immune response dynamics"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0114-6445","authenticated-orcid":false,"given":"Ester","family":"Donat","sequence":"first","affiliation":[{"name":"Paediatric Gastroenterology and Hepatology Unit Hospital Universitario y Polit\u00e9cnico La Fe Valencia Spain"},{"name":"Unidad de Enfermedad Celiaca e Inmunopatolog\u00eda Digestiva, Instituto de Investigaci\u00f3n Sanitaria La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0554-2629","authenticated-orcid":false,"given":"Ilma","family":"Korponay\u2010Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Coeliac Disease Centre, Heim P\u00e1l National Paediatric Institute, Budapest University of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6958-1251","authenticated-orcid":false,"given":"Renata","family":"Auricchio","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, and European Laboratory for the Investigation of Food Induced Disease (ELFID) University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7277-4767","authenticated-orcid":false,"given":"Marco","family":"Crocco","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victorien M.","family":"Wolters","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology University Medical Centre Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5772-5091","authenticated-orcid":false,"given":"Joanna","family":"Bier\u0142a","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology The Children Memorial Health Institute Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4109-2047","authenticated-orcid":false,"given":"Caroline","family":"Meijer\u2010Boekel","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Leiden University Medical Centre \u2010 Willem Alexander Children's Hospital Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2294-4478","authenticated-orcid":false,"given":"Peter","family":"Gillett","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Royal Hospital for Children and Young People Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4832-2714","authenticated-orcid":false,"given":"Gieneke Gonera\u2010de","family":"Jong","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Wilhelmina Hospital Assen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6737-075X","authenticated-orcid":false,"given":"Gemma","family":"Castillejo","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology Unit Hospital Universitario Sant Joan de Reus Reus Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5198-7130","authenticated-orcid":false,"given":"Margreet","family":"Wessels","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Rijnstate Hospital Arnhem Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6103-2191","authenticated-orcid":false,"given":"Josefa","family":"Barrio\u2010Torres","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology Unit, Hospital Fuenlabrada Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henedina","family":"Antunes","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology Hepatology and Nutrition Unit and Academic Clinical Cente, Hospital de Braga Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1944-3536","authenticated-orcid":false,"given":"Zrinjka","family":"Misak","sequence":"additional","affiliation":[{"name":"Referral Centre for Paediatric Gastroenterology and Nutrition Children's Hospital Zagreb, Hospital Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7809-5762","authenticated-orcid":false,"given":"Alina","family":"Popp","sequence":"additional","affiliation":[{"name":"National Institute for Mother and Child Health University of Medicine and Pharmacy \u201cCarol Davila\u201d Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6676-5773","authenticated-orcid":false,"given":"Alice","family":"Monzani","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Division of Paediatrics Universit\u00e0 del Piemonte Orientale Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8696-7025","authenticated-orcid":false,"given":"Raquel","family":"Vecino","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Hospital Universitario Cl\u00ednico San Carlos Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8157-2446","authenticated-orcid":false,"given":"Mar\u00eda","family":"Roca","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedad Celiaca e Inmunopatolog\u00eda Digestiva, Instituto de Investigaci\u00f3n Sanitaria La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Ribes\u2010Koninck","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedad Celiaca e Inmunopatolog\u00eda Digestiva, Instituto de Investigaci\u00f3n Sanitaria La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ESPGHAN Celiac Disease Special Interest Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2019.100025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737927"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.02.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-018-3248-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13176"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2015.1081565"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-023-00826-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-019-08756-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-023-09420-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8632861"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529209000089"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63329-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.9.6.1295-1300.2002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-021-07204-x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.11.1567"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002634"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91819-P"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199910000-00019"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003620"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.002"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003540"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001270"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-023-01040-1"},{"key":"e_1_2_9_27_1","first-page":"106","article-title":"Detection and quantification of gluten immunogenic peptides in feces of infants and their relationship with diet","volume":"111","author":"Roca M","journal-title":"Rev Esp Enferm Dig n.d."},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-020-02404-z"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70589","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70589","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:41:03Z","timestamp":1790660463000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":27,"alternative-id":["10.1002\/jpn3.70589"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70589","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]},"article-number":"jpn3.70589"}}