{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:04:50Z","timestamp":1790064290404,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23HL173704"],"award-info":[{"award-number":["K23HL173704"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Children with sickle cell disease (SCD) are at increased risk of developing gallstones, a common etiology of acute pancreatitis (AP). We aimed to determine if children with SCD admitted to children's hospitals for AP will have an increased burden of AP compared to non\u2010SCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective study of children 0\u221221 years admitted with a diagnosis of AP in the Pediatric Health Information System (PHIS) database from 2012 to 2023. Descriptive statistics were used to describe baseline demographics. Categorical variables including readmissions, complications, transfusions, and procedure rates were compared between groups (SCD vs. non\u2010SCD) using\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      or Fisher's exact test. Wilcoxon rank sum test was used to compare the median age and length of stay (LOS) between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We analyzed 18,213 distinct participants (17,927 [non\u2010SCD] and 286 [SCD]). Children with SCD were older;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0004 compared to non\u2010SCD. Children with SCD had increased LOS compared to those without SCD; 4 versus 3 days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;0.001. Further, children with SCD received more transfusions compared to those without SCD (31% vs. 3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;0.0001). Need for endoscopic interventions in SCD was 21% versus 8% in non\u2010SCD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), and cholecystectomy rates were higher in SCD, 33% compared to 11% in non\u2010SCD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with SCD hospitalized with AP at children's hospitals are older, need more red blood cell transfusions, have an increased LOS, and need more procedures compared to children without SCD. Further studies aimed at reducing the burden of AP in children with SCD are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70590","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:20:02Z","timestamp":1790061602000},"source":"Crossref","is-referenced-by-count":0,"title":["Children with sickle cell disease hospitalized for acute pancreatitis have an increased disease burden"],"prefix":"10.1002","author":[{"given":"Olawale","family":"Oduru","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8872-8076","authenticated-orcid":false,"given":"AKM Fazlur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyanam Kabir","family":"Baig KR","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3016-9299","authenticated-orcid":false,"given":"Saskia","family":"D'Sa","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaundra","family":"Blakemore","sequence":"additional","affiliation":[{"name":"Division of Pediatric Emergency Medicine, Department of Pediatrics University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2435-3655","authenticated-orcid":false,"given":"Chinenye R.","family":"Dike","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1182\/bloodadvances.2021006281","article-title":"Lifetime medical costs attributable to sickle cell disease among nonelderly individuals with commercial insurance","volume":"7","author":"Johnson KM","year":"2023","journal-title":"Blood Adv"},{"issue":"4","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"S512","DOI":"10.1016\/j.amepre.2009.12.022","article-title":"Population estimates of sickle cell disease in the U.S","volume":"38","author":"Hassell KL","year":"2010","journal-title":"Am J Prev Med"},{"issue":"12","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.30699","article-title":"Gastrointestinal symptoms, diagnostic evaluations, and abdominal pathology in children with sickle cell disease","volume":"70","author":"Dike CR","year":"2023","journal-title":"Pediatr Blood Cancer"},{"issue":"4","key":"e_1_2_9_5_1","article-title":"Pancreatitis in the setting of vaso\u2010occlusive sickle cell crisis: a rare encounter","volume":"9","author":"Hasan B","year":"2017","journal-title":"Cureus"},{"issue":"16","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13164712","article-title":"Acute pancreatitis in individuals with sickle cell disease: a systematic review","volume":"13","author":"Dike CR","year":"2024","journal-title":"J Clin Med"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2431-14-199","article-title":"Pediatric complex chronic conditions classification system version 2: updated for ICD\u201010 and complex medical technology dependence and transplantation","volume":"14","author":"Feudtner C","year":"2014","journal-title":"BMC Pediatr"},{"key":"e_1_2_9_8_1","article-title":"Pancreatitis in children with sickle cell disease (SCD)","volume":"55","author":"Sakhalkar V","year":"2004","journal-title":"Pediatr Res"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.14309\/00000434-200809001-00236","article-title":"Prevalance of acute pancreatitis in sickle cell disease: 236","volume":"103","author":"Jasti S","year":"2008","journal-title":"J Am Coll Gastroenterol"},{"issue":"5","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.7326\/0003-4819-102-5-576","article-title":"Diagnostic assays in acute pancreatitis. A study of sensitivity and specificity","volume":"102","author":"Steinberg WM","year":"1985","journal-title":"Ann Intern Med"},{"issue":"5","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/00006676-198709000-00003","article-title":"Serum pancreatic enzyme behavior during the course of acute pancreatitis","volume":"2","author":"Ventrucci M","year":"1987","journal-title":"Pancreas"},{"issue":"4","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.18773\/austprescr.2015.043","article-title":"Abnormal laboratory results: blood tests for acute pancreatitis","volume":"38","author":"Basnayake C","year":"2015","journal-title":"Aust Prescr"},{"issue":"1","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","article-title":"Classification of acute pancreatitis\u20142012: revision of the Atlanta classification and definitions by international consensus","volume":"62","author":"Banks PA","year":"2013","journal-title":"Gut"},{"issue":"11","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.29863","article-title":"Age\u2010 and sex\u2010specific rates of gall bladder disease in children with sickle cell disease","volume":"69","author":"Agawu A","year":"2022","journal-title":"Pediatr Blood Cancer"},{"issue":"3","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.67481\/ajps.v21i3.1041","article-title":"Presentation of acute pancreatitis in sickle cell disease patients: a single hospital experience","volume":"21","author":"Al\u2010Hindi S","year":"2024","journal-title":"Afr J Paediatr Surg"},{"issue":"1","key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bjhh.2016.09.009","article-title":"Cholelithiasis and its complications in sickle cell disease in a university hospital","volume":"39","author":"Martins RA","year":"2017","journal-title":"Rev Bras Hematol Hemoter"},{"issue":"9","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/jgh3.12622","article-title":"Correlates of gallbladder stones among patients with sickle cell disease: a meta\u2010analysis","volume":"5","author":"Mohamed SOO","year":"2021","journal-title":"JGH Open"},{"issue":"5","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jpeds.2004.06.071","article-title":"Outcomes for children with gallbladder abnormalities and sickle cell disease","volume":"145","author":"Suell MN","year":"2004","journal-title":"J Pediatr"},{"issue":"2","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s00464-005-0318-z","article-title":"Laparoscopic cholecystectomy in children with chronic hemolytic anemia. Is the outcome related to the timing of the procedure?","volume":"20","author":"Curr\u00f2 G","year":"2006","journal-title":"Surg Endosc"},{"issue":"8","key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1097\/MPA.0000000000001111","article-title":"Cholecystectomy during index admission for acute biliary pancreatitis lowers 30\u2010day readmission rates","volume":"47","author":"Krishna SG","year":"2018","journal-title":"Pancreas"},{"issue":"5","key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1007\/s00464-024-10790-2","article-title":"Index admission cholecystectomy for biliary acute pancreatitis or choledocholithiasis reduces 30\u2010day readmission rates in children","volume":"38","author":"Pathak SJ","year":"2024","journal-title":"Surg Endosc"},{"issue":"6","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.gie.2018.10.001","article-title":"ASGE guideline on the role of endoscopy in the evaluation and management of choledocholithiasis","volume":"89","author":"Buxbaum JL","year":"2019","journal-title":"Gastrointest Endosc"},{"issue":"14","key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.3748\/wjg.v17.i14.1844","article-title":"Role of ERCP in the era of laparoscopic cholecystectomy for the evaluation of choledocholithiasis in sickle cell anemia","volume":"17","author":"Issa H","year":"2011","journal-title":"World J Gastroenterol"},{"issue":"2","key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/jpr3.12039","article-title":"Gallbladder remnant: a potential source for biliary stones postcholecystectomy; a case report in a child with sickle cell disease","volume":"5","author":"Miri A","year":"2024","journal-title":"JPGN Rep"},{"issue":"1","key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/0049475514552550","article-title":"Complications of ERCP for choledocholithiasis in a sickle cell cohort","volume":"45","author":"Cawich SO","year":"2015","journal-title":"Trop Doct"},{"issue":"5","key":"e_1_2_9_26_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.transci.2023.103764","article-title":"Global burden of transfusion in sickle cell disease","volume":"62","author":"Inusa BP","year":"2023","journal-title":"Transfus Apher Sci"},{"issue":"3","key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.hoc.2016.01.011","article-title":"Management of patients with sickle cell disease using transfusion therapy","volume":"30","author":"Chou ST","year":"2016","journal-title":"Hematol Oncol Clin North Am"},{"issue":"1","key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1182\/asheducation-2016.1.625","article-title":"Sickle cell disease: when and how to transfuse","volume":"2016","author":"Howard J","year":"2016","journal-title":"Hematology"},{"issue":"9870","key":"e_1_2_9_29_1","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S0140-6736(12)61726-7","article-title":"The transfusion alternatives preoperatively in sickle cell disease (TAPS) study: a randomised, controlled, multicentre clinical trial","volume":"381","author":"Howard J","year":"2013","journal-title":"Lancet"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70590","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:20:06Z","timestamp":1790061606000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":28,"alternative-id":["10.1002\/jpn3.70590"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70590","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]},"article-number":"jpn3.70590"}}