{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:39:17Z","timestamp":1792607957985,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Accepting a suitable donor for a child awaiting pediatric liver transplantation (pLT) is increasingly challenging. Donor\u2010specific risk factors influence post\u2010transplant outcomes, but evidence in pediatric patients remains inconsistent. We aimed to identify their influence on mortality and graft loss and investigate their dependence on recipient\u2010 and transplant\u2010associated variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 954 consecutive pLT cases (1983\u20132024). Patient and graft survival was analyzed and correlated to donor\u2010 and graft\u2010specific variables by univariate and multivariate regression analyses, with a subgroup analysis for time era and indication for pLT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariate analysis showed that patient\/graft survival was significantly impaired by elevated donor creatinine (hazard ratio [HR]: 1.951\/1.728,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011\/0.007) and cerebrovascular cause of death (HR: 1.691\/3.797,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020\/&lt;0.001). ABO\u2010incompatible pLT negatively correlated with patient survival (HR, 2.628;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Prolonged cold ischemic time (HR: 2.912,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and donor age &gt;50 years (HR: 1.623,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042) impaired graft survival. Living donor liver transplantation (LDLT) showed improved patient survival (HR: 0.267,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The impact varied clearly by era and indication, as creatinine and AB0\u2010incompatible pLT showed a significant impact only up to 2006, while higher donor age impaired graft survival in the current era. Cold ischemic time affected graft survival only in recipients with chronic cirrhotic liver disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results strengthen the position of LDLT in pLT in current times of organ shortages. Newly identified donor\u2010specific risk factors as renal impairment alongside confirmed factors, like advanced donor age, prolonged CIT and cerebrovascular disease, help to identify marginal donors. Their impact is clearly dependent on recipient and transplant conditions, which underlines the importance of individually tailored donor profiles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70593","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:56:52Z","timestamp":1791788212000},"source":"Crossref","is-referenced-by-count":0,"title":["Heterogeneous effects of donor\u2010related risk factors in 954 pediatric liver transplantations"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-8728","authenticated-orcid":false,"given":"Christoph","family":"Leiskau","sequence":"first","affiliation":[{"name":"Department of Pediatric Kidney, Liver and Metabolic Diseases, Division of Pediatric Gastroenterology, Hepatology and Liver Transplantation Hannover Medical School Hannover Germany"},{"name":"Pediatric Gastroenterology, Department of Pediatrics and Adolescent Health University Medicine Goettingen Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Junge","sequence":"additional","affiliation":[{"name":"Department of Pediatric Kidney, Liver and Metabolic Diseases, Division of Pediatric Gastroenterology, Hepatology and Liver Transplantation Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Laue","sequence":"additional","affiliation":[{"name":"Department of Pediatric Kidney, Liver and Metabolic Diseases, Division of Pediatric Gastroenterology, Hepatology and Liver Transplantation Hannover Medical School Hannover Germany"},{"name":"Pediatric Gastroenterology, Department of General Pediatrics, Adolescent Medicine and Neonatology Medical Center\u2010University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imeke","family":"Goldschmidt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Kidney, Liver and Metabolic Diseases, Division of Pediatric Gastroenterology, Hepatology and Liver Transplantation Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke E.","family":"Mutschler","sequence":"additional","affiliation":[{"name":"Department of Pediatric Kidney, Liver and Metabolic Diseases, Division of Pediatric Gastroenterology, Hepatology and Liver Transplantation Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Schmelzle","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Felgendreff","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius J.","family":"van Beekum","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian W. R.","family":"Vondran","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery Hannover Medical School Hannover Germany"},{"name":"Department of General, Visceral, Pediatric and Transplant Surgery University Hospital RWTH Aachen Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara A.","family":"Weigle","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery Hannover Medical School Hannover Germany"},{"name":"Department of General, Visceral, Pediatric and Transplant Surgery University Hospital RWTH Aachen Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva\u2010D.","family":"Pfister","sequence":"additional","affiliation":[{"name":"Department of Pediatric Kidney, Liver and Metabolic Diseases, Division of Pediatric Gastroenterology, Hepatology and Liver Transplantation Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Baumann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Kidney, Liver and Metabolic Diseases, Division of Pediatric Gastroenterology, Hepatology and Liver Transplantation Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02211.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2002.34149"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200201000-00016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01357.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i12.1352"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23393"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.26218"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01242.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04195.x"},{"key":"e_1_2_8_11_1","first-page":"262","article-title":"A 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