{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:04:12Z","timestamp":1791288252732,"version":"4.3.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Regular monitoring of urinary electrolyte excretion and kidney function is essential in children with intestinal failure (IF) receiving long\u2010term parenteral nutrition (PN). This study evaluated alternative urine sampling methods against 24\u2010h urine collection (UC) and assessed the prevalence of chronic kidney disease (CKD) and renal abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective single\u2010centre cohort study, 31 paediatric IF patients underwent 24\u2010h UC, spot urine (SU) sampling, and shorter timed collections at predefined intervals. Urinary electrolytes and derived ratios were analysed. Kidney function was evaluated using cystatin C (CysC)\u2010 and creatinine (Cr)\u2010based estimated glomerular filtration rate (eGFR) and 24\u2010h urinary Cr clearance (CrCl). Agreement between alternative sampling methods and 24\u2010h UC was assessed using Bland\u2010Altman and regression analyses. Renal abnormalities were evaluated by ultrasound.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Shorter timed UCs, particularly those corresponding to the PN infusion interval, showed the closest agreement with 24\u2010h UC for sodium, magnesium, calcium, and phosphate excretion. Certain SU samples detected electrolyte deficiencies, particularly sodium and magnesium depletion, and low sodium\u2010to\u2010potassium ratios, highlighting cyclic dehydration at the end of the PN\u2010free interval. CKD was detected in 15\/30 patients (50%) by creatinine\u2010cysC\u2010based eGFR. Proteinuria was present in 17\/29 patients (58.6%) in 24\u2010h UC, and albuminuria in 13\/26 SU samples (50%). Nephrocalcinosis was found in 37% of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Shorter timed UC and targeted SU samples may provide practical alternatives to 24\u2010h UC for monitoring urinary electrolyte status and hydration. CKD and renal abnormalities are prevalent in children with IF receiving PN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70597","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:52:42Z","timestamp":1790329962000},"source":"Crossref","is-referenced-by-count":0,"title":["Urine diagnostics in paediatric intestinal failure: A prospective cohort study of alternative sampling methods"],"prefix":"10.1002","author":[{"given":"Anna","family":"Sakaeva","sequence":"first","affiliation":[{"name":"Paediatric Gastroenterology and Hepatology, Department of General Paediatrics and Haematology\/Oncology University Children's Hospital T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Busch","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology and Hepatology, Department of General Paediatrics and Haematology\/Oncology University Children's Hospital T\u00fcbingen T\u00fcbingen Germany"},{"name":"Paediatric Gastroenterology and Hepatology Children's Hospital Princess Margaret Darmstadt Darmstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8032-4096","authenticated-orcid":false,"given":"Johannes","family":"Holle","sequence":"additional","affiliation":[{"name":"Paediatric Nephrology, Department of General Paediatrics and Haematology\/Oncology University Children's Hospital T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4288-3828","authenticated-orcid":false,"given":"Hendrik","family":"Bartolomaeus","sequence":"additional","affiliation":[{"name":"Institute of Experimental Biomedicine University Hospital W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Fode","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics and Haematology\/Oncology University Children's Hospital T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7166-4689","authenticated-orcid":false,"given":"Ilias","family":"Tsiflikas","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1489-8662","authenticated-orcid":false,"given":"Ekkehard","family":"Sturm","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology and Hepatology, Department of General Paediatrics and Haematology\/Oncology University Children's Hospital T\u00fcbingen T\u00fcbingen 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