{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:45:40Z","timestamp":1791877540292,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Pediatric intussusception is the most common cause of acute intestinal obstruction in young children. We investigated long\u2010term epidemiological trends in pediatric intussusception before and after rotavirus vaccine introduction and during the COVID\u201019 pandemic in Hokkaido, Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective multicenter surveillance study was conducted at 17 hospitals in Hokkaido between 2007 and 2024. Clinical characteristics, management, outcomes, and viral antigen test results were collected. Only cases fulfilling Brighton Level 1 diagnostic certainty were included. Annual incidence rates were calculated using regional population statistics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 513 children met the inclusion criteria, with 93.0% aged 0\u20134 years. Non\u2010surgical reduction was successful in 94.0% of cases, and no deaths or long\u2010term sequelae were observed. Among infants aged &lt;1 year, incidence decreased from 99.4 per 100,000 person\u2010years during the pre\u2010vaccination period (2007\u20132011) to 69.9 during the voluntary vaccination period (2012\u20132019), and was 79.7 during the universal vaccination\/COVID\u201019 period (2020\u20132024). Corresponding incidence rates among children aged 0\u20134 years were 55.4, 36.7, and 38.1 per 100,000 person\u2010years, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among children aged 0\u20134 years, intussusception incidence was lower during the period following rotavirus vaccine introduction than during the pre\u2010vaccine period and remained broadly stable during the universal vaccination and COVID\u201019 period. The observed changes cannot be attributed to rotavirus vaccination alone because of concurrent changes in infectious disease circulation and other population\u2010level factors. Continued surveillance is warranted to further clarify the epidemiology of pediatric intussusception.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70599","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:53:43Z","timestamp":1791874423000},"source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010term trends in pediatric intussusception in Hokkaido, Japan, 2007\u20132024 across the rotavirus vaccination era"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9413-7224","authenticated-orcid":false,"given":"Yuya","family":"Fukuda","sequence":"first","affiliation":[{"name":"Department of Pediatrics Sapporo Medical University School of Medicine Sapporo Japan"},{"name":"Department of Pediatrics Japan Red Cross Urakawa Hospital Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Hokkaido Medical Center Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Kizawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Japan Community Health care Organization Sapporo Hokushin Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4909-5655","authenticated-orcid":false,"given":"Kenji","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics NTT Medical Center Sapporo Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Ikemoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sapporo Toho Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouhei","family":"Nishino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Otaru Kyokai Hospital Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiya","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Iwamizawa Municipal General Hospital Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sunagawa City Medical Center Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9304-072X","authenticated-orcid":false,"given":"Kazushige","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Takikawa Municipal Hospital Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minako","family":"Kihara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tomakomai City Hospital Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Steel Memorial Muroran Hospital Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8664-3761","authenticated-orcid":false,"given":"Hiroyuki","family":"Kabutoya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yakumo General Hospital Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Asakura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hokkaido Esashi Hospital Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2842-9733","authenticated-orcid":false,"given":"Yuta","family":"Sasaoka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hakodate Municipal Hospital Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kushiro City General Hospital Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Rumoi City Hospital Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7226-3000","authenticated-orcid":false,"given":"Takeshi","family":"Tsugawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sapporo Medical University School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ajem.2025.02.020","article-title":"High risk and low 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period (1978\u20132002)","volume":"134","author":"Nakagomi T","year":"2006","journal-title":"Epidemiol Infect"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.7883\/yoken.65.301","article-title":"Incidence of intussusception as studied from a hospital\u2010based retrospective survey over a 10\u2010year period (2001\u20132010) in Akita Prefecture, Japan","volume":"65","author":"Noguchi A","year":"2012","journal-title":"Jpn J Infect Dis"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2431-12-36","article-title":"Intussusception among Japanese children: an epidemiologic study using an administrative database","volume":"12","author":"Takeuchi M","year":"2012","journal-title":"BMC Pediatr"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jiac.2021.04.002","article-title":"Rotavirus vaccination in Japan: efficacy and safety of vaccines, changes in genotype, and surveillance efforts","volume":"27","author":"Tsugawa T","year":"2021","journal-title":"J Infect Chemother"},{"key":"e_1_2_9_9_1","unstructured":"JainS HaydelMJ. Child intussusception. In:StatPearls[Internet]. StatPearls Publishing; 2023."},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1097\/INF.0000000000002860","article-title":"Associations of intussusception with adenovirus, rotavirus, and other pathogens: a review of the literature","volume":"39","author":"Burnett E","year":"2020","journal-title":"Pediatr Infect Dis J"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.70967","article-title":"Recent increase in rotavirus gastroenteritis after five years of low activity in Hokkaido Prefecture, Japan, associated with equine\u2010like G3P[8] and G8P[8] strains, 2025","volume":"98","author":"Fukuda Y","year":"2026","journal-title":"J Med Virol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.jiac.2021.07.024","article-title":"Surveillance in hospitalized children with infectious diseases in Japan: pre\u2010 and post\u2010coronavirus disease 2019","volume":"27","author":"Fukuda Y","year":"2021","journal-title":"J Infect Chemother"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/INF.0000000000003982","article-title":"Changing patterns of infectious diseases among hospitalized children in Hokkaido, Japan, in the post\u2010COVID\u201019 era, July 2019 to June 2022","volume":"42","author":"Fukuda Y","year":"2023","journal-title":"Pediatr Infect Dis J"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.29299","article-title":"Resurgence of human metapneumovirus infection and influenza after three seasons of inactivity in the post\u2010COVID\u201019 era in Hokkaido, Japan, 2022\u20102023","volume":"95","author":"Fukuda Y","year":"2023","journal-title":"J Med Virol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.29780","article-title":"A significant outbreak of respiratory human adenovirus infections among children aged 3\u20106 years in Hokkaido, Japan, in 2023","volume":"96","author":"Fukuda Y","year":"2024","journal-title":"J Med Virol"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"e473","DOI":"10.1097\/INF.0000000000004927","article-title":"Reemergence of mycoplasma pneumoniae in post\u2010COVID\u201019 Japan: a 2024 outbreak in Hokkaido after 5 years","volume":"44","author":"Fukuda Y","year":"2025","journal-title":"Pediatr Infect Dis J"},{"key":"e_1_2_9_17_1","first-page":"9040","article-title":"Impact of the COVID\u201019 pandemic on the incidence of intussusception: a systematic review","volume":"26","author":"Yoon SH","year":"2022","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/apa.16656","article-title":"Characteristics of intussusception among children in Hokkaido, Japan, during the pre\u2010 and post\u2010rotavirus vaccine eras (2007\u20132016)","volume":"112","author":"Fukuda Y","year":"2023","journal-title":"Acta Paediatr (Stockholm)"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.vaccine.2003.09.016","article-title":"Acute intussusception in infants and children as an adverse event following immunization: case definition and guidelines of data collection, analysis, and presentation","volume":"22","author":"Bines JE","year":"2004","journal-title":"Vaccine"},{"key":"e_1_2_9_20_1","unstructured":"The number of routine vaccinations administered (in Japanese). Ministry of Health Labour and Welfare Japan. Accessed July 11 2026.https:\/\/www.mhlw.go.jp\/topics\/bcg\/other\/5.html"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"5717","DOI":"10.1016\/j.vaccine.2019.06.058","article-title":"Intussusception among Norwegian children: what to expect after introduction of rotavirus vaccination?","volume":"37","author":"Bruun T","year":"2019","journal-title":"Vaccine"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1542\/peds.2004-0390","article-title":"Intussusception in early childhood: a cohort study of 1.7 million children","volume":"114","author":"K\u00f8lsen Fischer T","year":"2004","journal-title":"Pediatrics"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1440-1754.2005.00686.x","article-title":"Changing epidemiology of intussusception in Australia","volume":"41","author":"Justice F","year":"2005","journal-title":"J Paediatr Child Health"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1016\/j.vaccine.2013.06.084","article-title":"Intussusception incidence among infants in the UK and Republic of Ireland: a pre\u2010rotavirus vaccine prospective surveillance study","volume":"31","author":"Samad L","year":"2013","journal-title":"Vaccine"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1056\/NEJMoa1012952","article-title":"Intussusception risk and health benefits of rotavirus vaccination in Mexico and Brazil","volume":"364","author":"Patel MM","year":"2011","journal-title":"N Engl J Med"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa1311738","article-title":"Risk of intussusception after monovalent rotavirus vaccination","volume":"370","author":"Weintraub ES","year":"2014","journal-title":"N Engl J Med"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa1303164","article-title":"Intussusception risk after rotavirus vaccination in U.S. infants","volume":"370","author":"Yih WK","year":"2014","journal-title":"N Engl J Med"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/498318","article-title":"Development and maturation of the immune system in preterm neonates: results from a whole genome expression study","volume":"2014","author":"Zasada M","year":"2014","journal-title":"BioMed Res Int"}],"container-title":["Journal of Pediatric Gastroenterology and Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpn3.70599","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpn3.70599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:53:48Z","timestamp":1791874428000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpn3.70599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":27,"alternative-id":["10.1002\/jpn3.70599"],"URL":"https:\/\/doi.org\/10.1002\/jpn3.70599","archive":["Portico"],"relation":{},"ISSN":["0277-2116","1536-4801"],"issn-type":[{"value":"0277-2116","type":"print"},{"value":"1536-4801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]},"article-number":"jpn3.70599"}}