{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:54:06Z","timestamp":1791975246275,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop an anthropometric\u2010based algorithm for estimating feeding tube (FT) insertion depth in neonates using retrospectively collected radiographic data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational study reviewed records of infants admitted to a Danish level IV Neonatal Intensive Care Unit from January 2023 to December 2024. Infants with FT placement, using the conventional Nose\u2013Ear\u2013Xiphoid (NEX) method, and radiographic verification within 24\u2009h were included. Radiographically verified FT position and anthropometric data were used to develop new linear and multivariate quadratic models to optimize placement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 198 infants were included (median gestational age [GA] of 35\u2009+\u20090 weeks [interquartile range, IQR:28\u2009+\u20096\u201338\u2009+\u20091]), 301 radiographic images showed, 144 FTs located at lumbar vertebra 1 (L1), 139 within one vertebra of L1, and 18 outside the stomach. Radiologists recommended adjustment in 107 images. Linear models (weight\u2010 or length\u2010dependent) showed strong predictive power (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009&gt;\u20090.84), while the multivariate quadratic model reduced bias and achieved\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.88, confirmed by cross\u2010validation. Prediction accuracy within the predefined target range (L1\u2009\u00b1\u20091.5\u2009cm) was 77% n, compared with 64% of clinically acceptable NEX placed tubes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The optimal algorithm was: FT depth\u2009=\u2009\u22123.46\u2009+\u20090.00229\u2009\u00d7\u2009weight (g)\u2009\u2212\u20099.48\u2009\u00d7\u200910\n                      <jats:sup>\u22128<\/jats:sup>\n                      \u2009\u00d7\u2009weight (g)\n                      <jats:sup>2<\/jats:sup>\n                      \u2009+\u20090.5992\u2009\u00d7\u2009length (cm) \u22120.005918\u2009\u00d7\u2009length(cm)\n                      <jats:sup>2<\/jats:sup>\n                      \u2009+\u20090.07808\u2009\u00d7\u2009correted GA(w).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The quadratic prediction model showed good internal performance and reduced bias at anthropometric extremes, offering a standardized approach to optimize FT placement and enhance safety in neonatal care. Prospective external validation is required before clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70608","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:40:14Z","timestamp":1791974414000},"source":"Crossref","is-referenced-by-count":0,"title":["Development of an anthropometric\u2010based algorithm to estimate feeding tube insertion depth in neonates"],"prefix":"10.1002","author":[{"given":"Julius V.","family":"Lauritsen","sequence":"first","affiliation":[{"name":"Department of Neonatology Copenhagen University Hospital Rigshospitalet Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Heiring","sequence":"additional","affiliation":[{"name":"Department of Neonatology Copenhagen University Hospital Rigshospitalet Denmark"},{"name":"Copenhagen Academy for Medical Education and Simulation University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Wulff","sequence":"additional","affiliation":[{"name":"Department of Neonatology Copenhagen University Hospital Rigshospitalet Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2023-298X","authenticated-orcid":false,"given":"Susanne S.","family":"Kappel","sequence":"additional","affiliation":[{"name":"Department of Neonatology Copenhagen University Hospital Rigshospitalet Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0965-429X","authenticated-orcid":false,"given":"Lise","family":"Aunsholt","sequence":"additional","affiliation":[{"name":"Department of Neonatology Copenhagen University Hospital Rigshospitalet Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Dansk Kvalitetsdatabase for Nyf\u00f8dte (DKN); 2024 1\u2013122.https:\/\/www.sundk.dk\/kliniske-kvalitetsdatabaser\/dansk-kvalitetsdatabase-for-nyfoedte-dkn\/nyheder-fra-dansk-kvalitetsdatabase-for-nyfoedte-dkn\/aarsrapport-2024-fra-dansk-kvalitetsdatabase-for-nyfoedte\/"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.clp.2023.04.005","article-title":"The practice of enteral nutrition","volume":"50","author":"Salas AA","year":"2023","journal-title":"Clin Perinatol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.3390\/nu15092180","article-title":"Feeding difficulties in late preterm infants and their impact on maternal mental health and the mother\u2013infant relationship: a literature review","volume":"15","author":"Vizzari G","year":"2023","journal-title":"Nutrients"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089077","article-title":"Factors associated with exclusive breastfeeding of preterm infants. 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