{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:39:06Z","timestamp":1792607946650,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014264","name":"Association Francois Aupetit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014264","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Several conditions are associated with inflammatory bowel disease (IBD), including immune\u2010mediated inflammatory diseases (IMIDs), extraintestinal manifestations (EIMs), and psychiatric disorders. This study aimed to describe at population\u2010level the comorbidities and their relative burden in paediatric\u2010onset IBD (pIBD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      All patients diagnosed with Crohn's disease (CD) or ulcerative colitis (UC) before age 17 between 1988 and 2011 and recorded in the EPIMAD population\u2010based registry were retrospectively followed until 2013. Comorbidities included chronic diseases, obesity (defined as a body mass index [BMI]\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score &gt;1.645), and underweight (defined as a BMI\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score &lt;\u22122), conditions requiring hospitalisation, serious infections, pneumopathy, meningitis, pyelonephritis, IMID, and EIM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1344 patients were included (1007 CD, 337 UC), with a median age at diagnosis of 14.3 years (interquartile range 11.7\u201316.0). Over a median follow\u2010up of 8.3 years (4.3\u201313.9), 15.8% developed at least one EIM, 9.3% at least one IMID, 12.7% developed dermatological conditions, and 5.1% serious infections; 18.4% were classified as underweight and 8.5% as obese. Younger age at diagnosis (&lt;14 years) and more extensive disease were associated with an increased risk of EIM and underweight, while CD was independently associated with underweight (hazard ratio, 3.3; 95% confidence interval, 2.0\u20135.0). Patients with dermatological conditions or IMID were more frequently treated with biologic therapies. The incidence of obesity, IMID and dermatological conditions increased across the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this population\u2010based pIBD cohort, the most common conditions were underweight, IMID, dermatological diseases, EIM and obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70609","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:54:27Z","timestamp":1791975267000},"source":"Crossref","is-referenced-by-count":0,"title":["Chronic conditions associated with paediatric onset inflammatory bowel diseases: A population\u2010based study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1294-5039","authenticated-orcid":false,"given":"Nicolas","family":"Richard","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Univ Rouen Normandie, INSERM, Normandie Univ, ADEN UMR1073, \u201cNutrition, Inflammation and Microbiota\u2010Gut\u2010Brain Axis\u201d, CHU Rouen Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Leroyer","sequence":"additional","affiliation":[{"name":"Department of Public Health, Epidemiology, and Economic Health, EPIMAD Registry, Regional House of Clinical Research Lille University Hospital Lille France"},{"name":"Univ. Lille, INSERM, CHU Lille, U1286 \u2010 INFINITE \u2013 Institute for Translational Research in Inflammation Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Sarter","sequence":"additional","affiliation":[{"name":"Department of Public Health, Epidemiology, and Economic Health, EPIMAD Registry, Regional House of Clinical Research Lille University Hospital Lille France"},{"name":"Univ. Lille, INSERM, CHU Lille, U1286 \u2010 INFINITE \u2013 Institute for Translational Research in Inflammation Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Dupont","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Gastroenterology, Caen University Hospital Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Turck","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille, U1286 \u2010 INFINITE \u2013 Institute for Translational Research in Inflammation Lille France"},{"name":"Department of Pediatrics, CHU Lille, Division of Gastroenterology Hepatology, and Nutrition Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Le Havre Hospital Le Havre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Wils","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille, U1286 \u2010 INFINITE \u2013 Institute for Translational Research in Inflammation Lille France"},{"name":"Lille University Hospital, Gastroenterology Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Gower\u2010Rousseau","sequence":"additional","affiliation":[{"name":"Research and Public Health Unit Reims University Hospital Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Savoye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Univ Rouen Normandie, INSERM, Normandie Univ, ADEN UMR1073, \u201cNutrition, Inflammation and Microbiota\u2010Gut\u2010Brain Axis\u201d, CHU Rouen Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Guillon","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille, U1286 \u2010 INFINITE \u2013 Institute for Translational Research in Inflammation Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Ley","sequence":"additional","affiliation":[{"name":"Univ. Lille, INSERM, CHU Lille, U1286 \u2010 INFINITE \u2013 Institute for Translational Research in Inflammation Lille France"},{"name":"Department of Pediatrics, CHU Lille, Division of Gastroenterology Hepatology, and Nutrition Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathurin","family":"Fumery","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Amiens University Hospital Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"EPIMAD Study 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