{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:35:42Z","timestamp":1793014542277,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Diabetes mellitus type 1 (T1DM1) and celiac disease (CD) can coexist in a patient. The aim was to evaluate the characteristics of children with both CD and T1DM and children with CD alone and to compare normalization rates of tissue transglutaminase immunoglobulin A class antibodies (anti\u2010tTG IgA) normalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective longitudinal study included children with both T1DM and CD and children with CD alone found by family screening, followed up from 2013 to 2023. Anthropometric and serologic parameters were evaluated at the time of diagnosis and during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Included were 18 patients in T1DM\u2009+\u2009CD group (39% girls, median age 8.9 years) and 27 patients in CD group (52% girls, median age 8.8 years). There were no statistically significant differences in gender, age, anthropometry parameters, frequency of patients with initial anti\u2010tTG levels &gt;10 times of upper limit of normal (78% vs. 63%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05), frequency of follow\u2010up visits (1.06 visits\/year of follow\u2010up vs. 0.76,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05) and follow\u2010up period (4.3 vs. 3.89 years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The only statistically significant difference was in timing of anti\u2010tTG normalization. At 2 years after diagnosis anti\u2010tTG normalized in 56% of patients in T1DM1\u2009+\u2009CD versus 93% in CD alone group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). If only patients with high antibody titers were analyzed, the normalization was still slower in CD\u2009+\u2009T1DM group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>It takes longer to normalize anti\u2010tTG in children with coexisting T1DM and CD than in CD alone found by family screening. We suggest monitoring these patients more closely during the first years after the diagnosis of CD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70619","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:05:02Z","timestamp":1792134302000},"source":"Crossref","is-referenced-by-count":0,"title":["Delayed normalization of tissue transglutaminase antibodies in children with celiac disease and type 1 diabetes mellitus"],"prefix":"10.1002","author":[{"given":"Ana","family":"C\u030cala","sequence":"first","affiliation":[{"name":"Zagreb Health Centre\u2010Zapad Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zvonimir Marko","family":"S\u030ckugor","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Pulmonology, and Endocrinology with an Intensive Care Unit for Internal Medicine General Hospital of Sibenik\u2010Knin County \u0160ibenik 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