{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:40:34Z","timestamp":1792377634791,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. pediatr. gastroenterol. nutr."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Posterior urethral valves (PUV) are the most common cause of congenital urinary obstruction in male infants and may be associated with lower urinary tract symptoms (LUTS). The association between LUTS and chronic constipation (CC) in children, known as bladder and bowel dysfunction (BBD), has been extensively investigated. However, how primary urological obstruction may influence gastrointestinal function remains poorly investigated. This study aimed to assess the prevalence of CC in children with PUV and evaluate changes in bowel symptoms following endoscopic PUV ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective observational study at \u201cSantobono\u2010Pausilipon Children's Hospital\u201d in Naples, Italy, from January 2021 to March 2024. Patients aged 0\u20136 years with PUV were enrolled. Demographic and clinical data were collected, including age, valve type, urological signs and symptoms, comorbidities, ongoing therapies. Bowel habits were assessed at diagnosis and after PUV ablation using Rome IV criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and one children were enrolled (mean age\u2009\u00b1\u2009standard deviation\u2009=\u200932\u2009\u00b1\u200948.4 months). At baseline, 27\/101 (26.7%) met Rome IV criteria for CC. After PUV ablation, constipation resolved in 19\/27 patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), reducing overall constipation prevalence from 26.7% to 11.9% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Multivariate analysis did not identify predictors of constipation resolution.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children affected by PUV exhibit a likely increased prevalence of CC. Endoscopic PUV ablation leads to significant normalization of bowel function, supporting a bidirectional interplay between urinary and gastrointestinal systems. Larger controlled studies are needed to confirm these findings in order to clarify the underlying mechanisms and optimize long\u2010term care for affected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpn3.70622","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:05:41Z","timestamp":1792375541000},"source":"Crossref","is-referenced-by-count":0,"title":["Posterior urethral valve and chronic constipation: Association and clinical outcome following endoscopic ablation in children"],"prefix":"10.1002","author":[{"given":"Vera","family":"Manganaro","sequence":"first","affiliation":[{"name":"Department of Translational Medical Sciences, Section of Pediatrics Federico II University Hospital Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Isoldi","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Unit Santobono\u2010Pausilipon Children's Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0734-7472","authenticated-orcid":false,"given":"Paolo","family":"Quitadamo","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Unit Santobono\u2010Pausilipon Children's Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Limansky","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Unit Santobono\u2010Pausilipon Children's Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Bucci","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Unit Santobono\u2010Pausilipon Children's Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giovanna","family":"Puoti","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Unit Santobono\u2010Pausilipon Children's Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Turco","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Unit Santobono\u2010Pausilipon Children's Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Dolce","sequence":"additional","affiliation":[{"name":"Biostatistics and Clinical Trial Methodology Unit, Clinical Research Center DEMeTra, Department of Translational Medical Science University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Santoro","sequence":"additional","affiliation":[{"name":"Pediatric Urology Unit Santobono\u2010Pausilipon Children's Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Torino","sequence":"additional","affiliation":[{"name":"Pediatric Urology Unit Santobono\u2010Pausilipon Children's Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"Roberti","sequence":"additional","affiliation":[{"name":"Pediatric Urology Unit Santobono\u2010Pausilipon Children's Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Farina","sequence":"additional","affiliation":[{"name":"Pediatric Urology Unit Santobono\u2010Pausilipon Children's Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Di","family":"Iorio","sequence":"additional","affiliation":[{"name":"Pediatric Urology Unit Santobono\u2010Pausilipon Children's Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Posterior Urethral Valves","author":"Bingham 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