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During the hospital course, he developed acute hepatic encephalopathy and was listed for liver transplantation, but fortunately recovered remaining status 7 (inactive) on the transplant list. With a negative diagnostic evaluation other than his viral infection and hyperdense CD8 T\u2010cells on liver immunohistochemical staining, pediatric acute liver failure (PALF) immune dysregulation phenotype was diagnosed.<\/jats:p>","DOI":"10.1002\/jpr3.12065","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T10:18:42Z","timestamp":1710757122000},"page":"204-207","source":"Crossref","is-referenced-by-count":1,"title":["Coronavirus HKU1 infection and development of pediatric acute liver failure with immune dysregulation phenotype"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2640-8070","authenticated-orcid":false,"given":"Arun","family":"Ajmera","sequence":"first","affiliation":[{"name":"Center for Digestive Health and Nutrition Arnold Palmer Hospital for Children Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Joseph","family":"Pernicone","sequence":"additional","affiliation":[{"name":"Advent Health at Orlando Advent Health for Children Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishant","family":"Patel","sequence":"additional","affiliation":[{"name":"Center for Digestive Health and Nutrition Arnold Palmer Hospital for Children Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefany Hernandez","family":"Benabe","sequence":"additional","affiliation":[{"name":"Advent Health Medical Group Pediatric Gastroenterology at Orlando Advent Health for Children Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.3390\/v1010057"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1128\/JVI.79.2.884-895.2005"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.3201\/eid1205.051316"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1086\/428510"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1097\/MPG.0000000000003404"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1056\/NEJMoa2206704"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1056\/NEJMoa2206294"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1016\/j.jpeds.2013.10.044"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1111\/petr.12296"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1097\/MPG.0b013e31827a78b2"},{"doi-asserted-by":"publisher","key":"e_1_2_7_12_1","DOI":"10.1016\/j.jhep.2008.08.009"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1002\/hep.28944"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.1002\/hep.29901"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.1016\/j.cld.2022.03.007"},{"doi-asserted-by":"publisher","key":"e_1_2_7_16_1","DOI":"10.1111\/his.13379"},{"doi-asserted-by":"publisher","key":"e_1_2_7_17_1","DOI":"10.1002\/hep.20111"},{"doi-asserted-by":"publisher","key":"e_1_2_7_18_1","DOI":"10.1016\/S2352-4642(23)00192-X"}],"container-title":["JPGN Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.12065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T03:18:45Z","timestamp":1715743125000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpr3.12065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,18]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/jpr3.12065"],"URL":"https:\/\/doi.org\/10.1002\/jpr3.12065","archive":["Portico"],"relation":{},"ISSN":["2691-171X","2691-171X"],"issn-type":[{"type":"print","value":"2691-171X"},{"type":"electronic","value":"2691-171X"}],"subject":[],"published":{"date-parts":[[2024,3,18]]}}}