{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:29:57Z","timestamp":1790195397709,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Dysphagia is a frequent symptom of active eosinophilic esophagitis (EoE), but at times it persists despite attaining histologic healing and lack of fibro\u2010stenotic changes. We aimed to describe the manometric findings in this subset of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of charts between 2013 and 2023 at a tertiary pediatric gastroenterology center, treating roughly 1500 EoE patients per year. We included children with EoE referred to high\u2010resolution impedance manometry (HRIM) for persistent dysphagia despite histologic healing (i.e., &lt;15 eosinophils\/high\u2010power field [Eos\/hpf]). Data including initial EoE diagnosis, endoscopy reports, esophageal biopsies, treatment regimens, and HRIM were retrospectively collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The estimated prevalence of post\u2010remission dysphagia in our cohort was exceedingly rare (&lt;0.05%). Four patients met the eligibility criteria of histologic remission and absence of fibro\u2010stenotic features on endoscopic evaluation and thus, were included in this case series. Patients achieved remission with steroids, proton\u2010pump inhibitor, or both within a median time of 5 months from diagnosis. Peak Eosinophil count at remission was \u22645\u2009Eos\/hpf in three patients and \u226410\u2009Eos\/hpf in one. On HRIM, all four patients had a hypomotile esophagus and abnormal bolus clearance. Lower esophageal sphincter integrated relaxation pressure values were normal in three patients and elevated in one. Two patients were diagnosed with ineffective esophageal motility, one with aperistalsis and one with achalasia type 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Post\u2010remission dysphagia is rare in EoE. Esophageal dysmotility with a hypomotile pattern may contribute to the persistent dysphagia in children with EoE. HRIM should be considered in patients with EoE in whom symptoms persist despite histologic remission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpr3.12083","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T04:30:19Z","timestamp":1716352219000},"page":"289-295","source":"Crossref","is-referenced-by-count":4,"title":["Manometric findings in children with eosinophilic esophagitis and persistent post\u2010remission dysphagia"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2431-0284","authenticated-orcid":false,"given":"Dotan","family":"Yogev","sequence":"first","affiliation":[{"name":"Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition Shaare Zedek Medical Center Jerusalem Israel"},{"name":"Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lev","family":"Dorfman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition University of Cincinnati College of Medicine Cincinnati Ohio USA"},{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherief","family":"Mansi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition University of Cincinnati College of Medicine Cincinnati Ohio USA"},{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"El\u2010Chammas","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition University of Cincinnati College of Medicine Cincinnati Ohio USA"},{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lyles","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition Duke University School of Medicine, Duke University Hospital Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Mukkada","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition University of Cincinnati College of Medicine Cincinnati Ohio USA"},{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kaul","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition University of Cincinnati College of Medicine Cincinnati Ohio USA"},{"name":"Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640616689525"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00128"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-022-00964-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.853754"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2023.10.048"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13239"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14120"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","unstructured":"MousaH PaulA. 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