{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:00:33Z","timestamp":1785448833510,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Pediatric autoimmune hepatitis has an incidence of 0.23\/100.000 children in North America, with a bleak prognosis if left untreated. Steroids are the therapy of choice but are not always effective. B cell depletion is a safe and effective therapy that allows for a steroid\u2010sparing protocol, especially in patients who do not tolerate side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed rituximab\u2010treated patients between 2017 and 2022. Demographics, previous treatments, reasons for B cell depletion, response, and adverse effects were noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six patients with a mean age of 10.2 years were included. All patients had comorbidities that rendered treatment with steroids unsuccessful or undesirable. Rituximab was started at a mean follow\u2010up of 8 months. After 6 months, the mean alanine transaminase and aspartate transaminase levels decreased from 575 IU\/L and 342 IU\/L, respectively, to 28 IU\/L (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and 36 IU\/L (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), respectively. Mean \u03b3\u2010glutamyl transpeptidase decreased from 105 to 25 IU\/L (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Immunoglobulin G levels were normalized in all patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). No severe adverse events were observed. One patient had persistent hypogammaglobulinemia, and another had lymphopenia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>B\u2010cell depletion is an effective and safe treatment for autoimmune liver diseases and should be included as an option, particularly for relapsing patients in whom steroids are undesirable or have shown nonadherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpr3.12098","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T06:29:23Z","timestamp":1718346563000},"page":"326-333","source":"Crossref","is-referenced-by-count":5,"title":["B cell depletion for autoimmune liver diseases: A retrospective review of indications and outcomes"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0468-5321","authenticated-orcid":false,"given":"Guillermo A.","family":"Costaguta","sequence":"first","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition CHU Sainte\u2010Justine Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition CHU Sainte\u2010Justine Montreal Quebec Canada"},{"name":"Department of Pediatrics University of Montreal Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.06.030"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2005.10.009"},{"issue":"1","key":"e_1_2_9_4_1","first-page":"53","article-title":"Autoimmune diseases of the liver and biliary tract and overlap syndromes in childhood","volume":"55","author":"Maggiore G","year":"2009","journal-title":"Minerva Gastroenterol Dietol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-0578"},{"issue":"2","key":"e_1_2_9_6_1","first-page":"169","article-title":"Hepatitis autoinmune en ni\u00f1os. 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