{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:23:04Z","timestamp":1792693384389,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Upadacitinib (UPA), a selective Janus kinase\u20101 inhibitor, has demonstrated efficacy in inducing and maintaining remission in moderate to severe ulcerative colitis (UC) in adults. Current standard management for acute severe ulcerative colitis (ASUC) involves intravenous corticosteroids (IVCS) followed by infliximab\u00a0(IFX) salvage therapy. Limited data exist on the utility of UPA in ASUC, particularly in adolescents. This case series reports the use of UPA as salvage therapy in hospitalized adolescents experiencing ASUC refractory to IFX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective chart review of hospitalized patients with ASUC who received UPA as salvage therapy after initiation of IVCS and failure of IFX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three adolescents were hospitalized with ASUC for which IFX infusion treatments were unsuccessful. Initiation of UPA enabled patients to improve their Pediatric Ulcerative Colitis Activity Index scores to \u226435 and be discharged home. Hospitalization course, complications, and follow\u2010up information are provided.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>UPA is a promising short\u2010term salvage therapy in adolescent ASUC cases resistant to conventional treatments. Prospective studies are warranted to elucidate its long\u2010term efficacy and safety in this specific population. These findings provide a novel therapeutic avenue for managing ASUC in adolescents, offering hope for those encountering treatment challenges.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jpr3.12124","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T07:27:05Z","timestamp":1725521225000},"page":"447-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Upadacitinib as salvage therapy in adolescents with acute severe ulcerative colitis refractory to conventional treatments"],"prefix":"10.1002","volume":"5","author":[{"given":"Andrew","family":"Dickerson","sequence":"first","affiliation":[{"name":"Department of Pediatrics,\u00a0Division of Gastroenterology University of California San Diego California USA"},{"name":"Rady Children's Hospital San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannie S.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0Division of Gastroenterology University of California San Diego California USA"},{"name":"Rady Children's Hospital San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9753-5946","authenticated-orcid":false,"given":"Laura E.","family":"Bauman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,\u00a0Division of Gastroenterology University of California San Diego California USA"},{"name":"Rady Children's Hospital San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2017.10.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1184"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.481"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.03.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002316"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606910"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00581-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.11.029"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41927-018-0031-x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318448"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20867"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712243172603"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2014.05.010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad300"},{"issue":"1","key":"e_1_2_7_16_1","first-page":"S021","article-title":"OP23 efficacy and safety of upadacitinib as induction therapy in patients with moderately to severely active ulcerative colitis: results from phase 3 U\u2010ACCOMPLISH study","volume":"15","author":"Vermeire S","year":"2021","journal-title":"J\u00a0Crohns\u00a0Colitis"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61084-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.09.033"},{"key":"e_1_2_7_19_1","unstructured":"Seattle Children's Hospital WahbehG BurnsB et al.CSW IBD Acute Severe Ulcerative Colitis Medical Management Pathway. 2023.https:\/\/www.seattlechildrens.org\/pdf\/IBD-ulcerative-colitis-medical-management-pathway.pdf"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.05.038"},{"key":"e_1_2_7_21_1","unstructured":"HigginsP WaljeeA et al.University of Michigan Severe Ulcerative Colitis Protocol. 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