{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:34:10Z","timestamp":1789842850813,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with hereditary spherocytosis (HS) often require red blood cell transfusions for the treatment of hemolytic anemia. Iron overload is a known complication of frequent transfusions. Deferasirox, an oral iron chelator, can cause transient elevations in serum aminotransferase levels. There have been a few cases demonstrating Deferasirox\u2010associated liver injury in patients with sickle cell anemia and thalassemia. In this case report, we present a 13\u2010year\u2010old male with transfusion\u2010dependent HS treated with Deferasirox who presented with jaundice and was found to have evidence of acute hepatocellular injury.<\/jats:p>","DOI":"10.1002\/jpr3.12155","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T09:29:43Z","timestamp":1734341383000},"page":"56-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Drug\u2010induced liver injury from Deferasirox in a pediatric patient with hereditary spherocytosis: A case report"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1391-4006","authenticated-orcid":false,"given":"Siddhant","family":"Talwar","sequence":"first","affiliation":[{"name":"Department of Pediatrics UCSF Benioff Children's Hospital\u2010Oakland Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Department of Pediatrics Children's Hospital Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhav","family":"Vissa","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Department of Pediatrics UCSF Benioff Children's Hospital\u2010Oakland Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Cort","sequence":"additional","affiliation":[{"name":"Division of Pediatric Radiology, Department of Pediatrics UCSF Benioff Children's Hospital\u2010Oakland Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Byers","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine UCSF San Fransisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5887-5454","authenticated-orcid":false,"given":"Sabina","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Department of Pediatrics UCSF Benioff Children's Hospital\u2010Oakland Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2021000265"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-157-1-201206190-00429"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.030833"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp060405"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181ec0c38"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26507"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000786"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000654"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.1040"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2015.5987"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18770"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003535"},{"key":"e_1_2_7_14_1","unstructured":"LiverTox: Clinical and Research Information on Drug\u2010Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012. Deferasirox. [Updated 2017 Dec 26]."}],"container-title":["JPGN Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.12155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T05:36:16Z","timestamp":1751434576000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpr3.12155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/jpr3.12155"],"URL":"https:\/\/doi.org\/10.1002\/jpr3.12155","archive":["Portico"],"relation":{},"ISSN":["2691-171X","2691-171X"],"issn-type":[{"value":"2691-171X","type":"print"},{"value":"2691-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,16]]},"assertion":[{"value":"2024-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}