{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:52:31Z","timestamp":1788306751933,"version":"build-2803163510"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The treatment options available for pediatric ulcerative colitis (UC) are challenging due to few with Federal Drug Administration approval. Newer medications approved for adults include additional biologics with differing mechanisms of action and small molecule drugs, such as Janus kinase (JAK) inhibitors. Our case outlines a patient with refractory UC who failed mesalamine, adalimumab, tofacitinib, and vedolizumab. She was evaluated for colectomy, but upadacitinib was trialed. She achieved rapid clinical remission and avoided surgery. This case demonstrates the failure of a pan\u2010JAK inhibitor (tofacitinib) and response to a more selective JAK 1 inhibitor (upadacitinib).<\/jats:p>","DOI":"10.1002\/jpr3.70005","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T10:20:51Z","timestamp":1739269251000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Have we hit the JAK\u2010pot? Success of selective JAK 1 inhibitor following failure of pan\u2010JAK inhibitor in refractory pediatric ulcerative colitis"],"prefix":"10.1002","author":[{"given":"Jessica A.","family":"Black","sequence":"first","affiliation":[{"name":"Phoenix Children's Hospital, Banner University Medical Center \u2013 Tucson University of Arizona Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1912-871X","authenticated-orcid":false,"given":"Brad","family":"Pasternak","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Phoenix Children's Hospital \u2013 Phoenix Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00966-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606910"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.11.029"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1993.tb00110.x"},{"issue":"33","key":"e_1_2_6_6_1","first-page":"564","article-title":"Ulcerative colitis\u2014diagnostic and therapeutic algorithms","volume":"117","author":"Kucharzik T","year":"2020","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21418"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15687"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81166-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00377-0"}],"container-title":["JPGN Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T10:20:54Z","timestamp":1739269254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpr3.70005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":9,"alternative-id":["10.1002\/jpr3.70005"],"URL":"https:\/\/doi.org\/10.1002\/jpr3.70005","archive":["Portico"],"relation":{},"ISSN":["2691-171X","2691-171X"],"issn-type":[{"value":"2691-171X","type":"print"},{"value":"2691-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,10]]},"assertion":[{"value":"2024-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jpr3.70005"}}