{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:24:42Z","timestamp":1786559082249,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This is a prospective, multicenter study of a cohort of 224 cystic fibrosis (CF) patients treated with CF transmembrane conductance regulator (CFTR) modulators (CFTRm). Our aim was to prospectively analyze the effect of CFTRm treatment on fat\u2010soluble vitamin serum levels. Demographic and clinical data were recorded, and fat\u2010soluble vitamin levels were analyzed at baseline, and at 6 and 12 months after starting treatment. Two groups were analyzed separately: patients receiving dual therapy lumacaftor\/ivacaftor or tezacaftor\/ivacaftor (Lum\/Tez+Iva), and those on triple therapy with elexacaftor\/tezacaftor\/ivacaftor (ETI). We found that treatment with ETI produced a significant increase in vitamin D and A levels within the first 6 months, which was maintained at 12 months. However, with dual therapy, we observed an increase only in vitamin A levels within the first 6 months, which was not maintained at 12 months. No differences were found in vitamin E serum levels between the groups.<\/jats:p>","DOI":"10.1002\/jpr3.70007","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T08:29:51Z","timestamp":1742200191000},"page":"146-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of cystic fibrosis modulator therapies on serum levels of fat\u2010soluble vitamins"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7135-6539","authenticated-orcid":false,"given":"Elena","family":"Crehu\u00e1\u2010Gaudiza","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition Section, Hospital Cl\u00ednico Universitario de Valencia University of Valencia Valencia 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