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This case report presents a 17\u2010year\u2010old male with abdominal pain, weight loss, and anemia who was diagnosed with LS\u2010associated adenocarcinoma of the colon in the setting of a mutS homolog 6 genetic mutation, which was confirmed by genetic testing. This highlights an urgent need to reevaluate current pediatric screening guidelines for hereditary cancer syndromes to prevent delayed diagnosis and improve outcomes. Family history\u2010taking, genetic screening, and aggressive surveillance practices should also be integrated into standard pediatric care protocols.<\/jats:p>","DOI":"10.1002\/jpr3.70039","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T03:14:43Z","timestamp":1749179683000},"page":"400-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A rare case of colonic adenocarcinoma in a pediatric patient"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2590-9504","authenticated-orcid":false,"given":"Christine","family":"Kaba","sequence":"first","affiliation":[{"name":"Children's Healthcare of Atlanta Atlanta Georgia USA"},{"name":"Department of Pediatrics Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey","family":"Chatman","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta Atlanta Georgia USA"},{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Hames","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta Atlanta Georgia USA"},{"name":"Division of Pediatric Hospital Medicine Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose E.","family":"Velazquez Vega","sequence":"additional","affiliation":[{"name":"Department of Pathology Children's Healthcare of Atlanta Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hillary","family":"Bashaw","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta Atlanta Georgia USA"},{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/jiaps.JIAPS_33_21"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000503"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13053-024-00280-w"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.epsc.2022.102431"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1166238"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920211797904070"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.23922\/jarc.2019-002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-018-00117-1"}],"container-title":["JPGN Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T04:02:32Z","timestamp":1763006552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpr3.70039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,6]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/jpr3.70039"],"URL":"https:\/\/doi.org\/10.1002\/jpr3.70039","archive":["Portico"],"relation":{},"ISSN":["2691-171X","2691-171X"],"issn-type":[{"type":"print","value":"2691-171X"},{"type":"electronic","value":"2691-171X"}],"subject":[],"published":{"date-parts":[[2025,6,6]]},"assertion":[{"value":"2024-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}