{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T04:04:33Z","timestamp":1763006673193,"version":"3.45.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Reactions to intravenous ustekinumab for inflammatory bowel disease (IBD) occur, the frequency of which is uncertain. It is unclear how often subcutaneous treatment is continued after reactions to the intravenous dose, or how well it is tolerated. We therefore conducted a retrospective cohort study of pediatric patients who initiated ustekinumab for Crohn's disease from 6 pediatric IBD centers in the United States. Ten of 207 (5%) patients had an infusion reaction to their induction ustekinumab dose. Of these, 6 (60%) restarted their infusion, five completed the infusion. Subsequently, eight patients were treated with subcutaneous ustekinumab, none of whom develop reactions. Reaction to intravenous induction ustekinumab occurs in 5% of patients. Subcutaneous ustekinumab is generally well tolerated after intravenous reaction.<\/jats:p>","DOI":"10.1002\/jpr3.70065","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T03:58:21Z","timestamp":1753329501000},"page":"451-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multicenter study of continuing ustekinumab after intravenous induction reactions in pediatric Crohn's disease"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0599-8192","authenticated-orcid":false,"given":"Joann","family":"Samalik","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology Michigan Medicine Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Singer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Michigan Medicine Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition UCSF Benioff Children's Hospital Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archana","family":"Anandakrishnan","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Phoenix Children's Hospital Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaella K.","family":"Baker","sequence":"additional","affiliation":[{"name":"Susan B. Meister Child Health Evaluation and Research Center University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Creps","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Pediatric Surgery University of Michigan Medical School Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"Khorrami","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Seattle Children's Hospital Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross M.","family":"Maltz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Nationwide Children's Hospital Columbus Ohio USA"},{"name":"Department of Pediatrics The Ohio State University Wexner Medical Center Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Manning","sequence":"additional","affiliation":[{"name":"Susan B. Meister Child Health Evaluation and Research Center University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Moses","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition UH Rainbow Babies &amp; Children's Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad","family":"Pasternak","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Phoenix Children's Hospital Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perseus V.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition UCSF Benioff Children's Hospital Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne C.","family":"Singer","sequence":"additional","affiliation":[{"name":"Susan B. Meister Child Health Evaluation and Research Center University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Suskind","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Seattle Children's Hospital Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Becca","family":"Trombler","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition UCSF Benioff Children's Hospital San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-6098","authenticated-orcid":false,"given":"Jeremy","family":"Adler","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Michigan Medicine Ann Arbor Michigan USA"},{"name":"Susan B. Meister Child Health Evaluation and Research Center University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the ImproveCareNow Pediatric IBD Learning Health System","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1056\/NEJMoa1900750"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1007\/s40272-023-00586-7"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1097\/MPG.0000000000002362"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1093\/ecco-jcc\/jjab089"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1093\/ecco-jcc\/jjaa202"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.14309\/crj.0000000000000449"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1097\/PG9.0000000000000293"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1097\/PG9.0000000000000205"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1016\/j.cgh.2024.03.043"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1097\/MPG.0000000000003230"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1093\/ecco-jcc\/jjaa115"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.1111\/j.1600-0536.2009.01569.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1002\/ajim.22036"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1016\/j.jaip.2013.12.001"}],"container-title":["JPGN Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T04:01:59Z","timestamp":1763006519000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpr3.70065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/jpr3.70065"],"URL":"https:\/\/doi.org\/10.1002\/jpr3.70065","archive":["Portico"],"relation":{},"ISSN":["2691-171X","2691-171X"],"issn-type":[{"type":"print","value":"2691-171X"},{"type":"electronic","value":"2691-171X"}],"subject":[],"published":{"date-parts":[[2025,7,23]]},"assertion":[{"value":"2024-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}