{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T05:22:37Z","timestamp":1770873757642,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary eosinophilic gastrointestinal disorders beyond the esophagus (EGIDs) are rare, predominantly Th2\u2010mediated inflammatory conditions, affecting various segments of the gastrointestinal tract. We report the case of a 12\u2010year\u2010old boy with recurrent abdominal pain, peripheral eosinophilia, and progressive gastritis, duodenitis, and enteritis with eosinophilic ascites. He was diagnosed with extensive EGID with muscular and serosal involvement. He was treated with oral corticosteroids and milk elimination diet, which provided temporary relief, but relapses prompted the addition of dupilumab, which achieved durable remission. To our knowledge, this is the first reported case demonstrating the effectiveness of this monoclonal antibody in EGIDs with serosal involvement and eosinophilic ascites. This case highlights the therapeutic potential of dupilumab in refractory EGID cases involving deeper gastrointestinal layers.<\/jats:p>","DOI":"10.1002\/jpr3.70113","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:48:44Z","timestamp":1762861724000},"page":"132-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Muscular and serosal eosinophilic gastritis and enteritis with eosinophilic ascites successfully treated with dupilumab"],"prefix":"10.1002","volume":"7","author":[{"given":"Almudena","family":"S\u00e1nchez\u2010Ram\u00edrez","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology Unit Hospital Universitario Puerta de Hierro Majadahonda Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8363-4760","authenticated-orcid":false,"given":"Alejandro","family":"Garc\u00eda\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Hospital Universitario Puerta de Hierro Majadahonda Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Garc\u00eda\u2010Mart\u00ednez de Bartolom\u00e9","sequence":"additional","affiliation":[{"name":"Department of Pediatrics EAP Valle de la Oliva Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Isabel","family":"Garc\u00eda\u2010Hidalgo","sequence":"additional","affiliation":[{"name":"Department of Radiology Hospital Universitario Puerta de Hierro Majadahonda Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luz","family":"Cilleruelo","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Hospital Universitario Puerta de Hierro Majadahonda Madrid Spain"},{"name":"Universidad Aut\u00f3noma de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enriqueta","family":"Rom\u00e1n\u2010Riechmann","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Hospital Universitario Puerta de Hierro Majadahonda Madrid Spain"},{"name":"Universidad Aut\u00f3noma de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0313-7072","authenticated-orcid":false,"given":"Carolina","family":"Guti\u00e9rrez\u2010Junquera","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Hospital Universitario Puerta de Hierro Majadahonda Madrid Spain"},{"name":"Universidad Aut\u00f3noma de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.03.013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.02.017"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003877"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000001187"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12187"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13973"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13010112"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003512"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-023-00859-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000646"}],"container-title":["JPGN Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpr3.70113","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T04:58:42Z","timestamp":1770872322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpr3.70113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,11]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/jpr3.70113"],"URL":"https:\/\/doi.org\/10.1002\/jpr3.70113","archive":["Portico"],"relation":{},"ISSN":["2691-171X","2691-171X"],"issn-type":[{"value":"2691-171X","type":"print"},{"value":"2691-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,11]]},"assertion":[{"value":"2025-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}