{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:33:06Z","timestamp":1781641986060,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100002491","name":"BMS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"publisher","award":["P30AR070253"],"award-info":[{"award-number":["P30AR070253"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"publisher","award":["R01AR083424"],"award-info":[{"award-number":["R01AR083424"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine if multiplex autoantibody arrays can identify novel biomarker signatures in children with one or multiple autoimmune diseases (polyautoimmunity).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Plasma collected from children (18 years or younger) in the Boston Children's Hospital Precision Link Biobank for Health Discovery between January 2007 and June 2021 was analyzed using a microarray with 120 autoantigens associated with various autoimmune diseases to assess for both immunoglobulin G (IgG) and A (IgA) autoantibodies. To determine if disease\u2010specific, we binary classified those with polyautoimmunity and the most common autoimmune diseases in our cohort (autoimmune thyroid disease, type 1 diabetes, or celiac disease [CeD]). For each comparison within and between groups, the autoantibody intensity was releveled to the control and a linear model was fit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Plasma was analyzed from 114 children with either CeD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931), juvenile idiopathic arthritis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920), polyautoimmunity (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931), or no autoimmune disease (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932). Overall, children with polyautoimmunity had higher levels of specific autoantibodies relative to the other groups. Children with CeD and polyautoimmunity expressed higher levels of H\/K ATPase IgA and IgG and MDA5 IgG compared to those with CeD alone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Use of multiplex antigen arrays in patients with and without polyautoimmunity is a valuable tool to identify known and potentially novel disease\u2010antigens. Further study is needed to determine the role of H\/K ATPase autoantibodies in monitoring of CeD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpr3.70119","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:42:34Z","timestamp":1763970154000},"page":"118-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Autoantibody signatures in children with celiac disease, juvenile idiopathic arthritis, and polyautoimmunity"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2728-917X","authenticated-orcid":false,"given":"Nan","family":"Du","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Nutrition Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Nutrition Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Nutrition Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay R.","family":"Thiagarajah","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Nutrition Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Michigan Medicine, C.S. Mott Children's Hospital University of Michigan Medical School Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Division of Immunology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnan","family":"Raghunathan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Nutrition Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn A.","family":"Silvester","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Nutrition Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00720-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/ITT.S450184"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.07.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2018-0066"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008562"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002418"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31796-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001435"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-020-00426-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00332-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00349"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/254319"},{"issue":"4","key":"e_1_2_8_14_1","first-page":"210","article-title":"Autoantigen microarray for high\u2010throughput autoantibody profiling in systemic lupus erythematosus","volume":"13","author":"Zhu H","year":"2015","journal-title":"Genom Insights"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.042"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85647"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw313"},{"key":"e_1_2_8_18_1","volume-title":"PCAtools: Everything Principal Components Analysis. 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