{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:11:29Z","timestamp":1778155889607,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pediatric patients with CD19+ acute lymphoblastic leukemia (ALL) undergoing chimeric antigen receptor T\u2010cell (CAR\u2010T) therapy frequently experience gastrointestinal (GI) complications. A retrospective study analyzed 13 patients (median age: 8 years) treated between January 2020 and January 2024. Seventy percent of patients experienced symptoms such as diarrhea (46%), abdominal pain (30%), and nausea\/vomiting (38%). Despite adequate nutritional tolerance in 70% of cases, 31% required parenteral nutrition. Chronic malnutrition prevalence increased from 23% at baseline to 30% 6 months after therapy. These findings highlight the significant impact of CAR\u2010T therapy on GI health and nutritional status in pediatric patients. The high incidence of GI side effects and the associated nutritional challenges underline the importance of implementing multidisciplinary care and close monitoring to mitigate these complications. Optimizing nutritional management could improve patient outcomes and inform strategies for future treatments in this vulnerable population. Further research is needed to refine supportive care approaches.<\/jats:p>","DOI":"10.1002\/jpr3.70130","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T07:09:56Z","timestamp":1766041796000},"page":"377-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastrointestinal manifestations following chimeric antigen receptor T\u2010cell (CAR\u2010T) 19 therapy in pediatric patients with CD19+ acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1768-896X","authenticated-orcid":false,"given":"Judith Raya","family":"Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology and Clinical Nutrition Unit Vall d'Hebron Hospital Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa Panesso","family":"Romero","sequence":"additional","affiliation":[{"name":"Pediatric Oncology and Hematology Service Vall d'Hebron Hospital Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saray Mesonero","family":"Cavia","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Clinical Nutrition Unit Vall d'Hebron Hospital Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta Freixas","family":"Bermejo","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Clinical Nutrition Unit Vall d'Hebron Hospital Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Cabello","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Clinical Nutrition Unit Vall d'Hebron Hospital Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina \u00c1lvarez","family":"Beltran","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Clinical Nutrition Unit Vall d'Hebron Hospital Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina D\u00edaz de Heredia","family":"Rubio","sequence":"additional","affiliation":[{"name":"Pediatric Oncology and Hematology Service Vall d'Hebron Hospital Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana Elena Redecillas","family":"Ferreiro","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Clinical Nutrition Unit Vall d'Hebron Hospital Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar Segarra","family":"Canton","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Clinical Nutrition Unit Vall d'Hebron Hospital Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"issue":"20","key":"e_1_2_8_2_1","first-page":"2","article-title":"Chimeric antigen receptor T\u2010cell therapy","volume":"181","author":"M\u00fcller K","year":"2019","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0075-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-022-04316-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000596"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-024-00752-0"},{"issue":"3","key":"e_1_2_8_7_1","first-page":"5","article-title":"The relevance of nutrition to pediatric oncology: a cancer control perspective","volume":"67","author":"Rogers PC","year":"2020","journal-title":"Pediatr Blood Cancer"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.229781"},{"key":"e_1_2_8_9_1","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) v5.0; 2018. 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