{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:49:47Z","timestamp":1783982987162,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014566","name":"Celiac Disease Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JPGN rep."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Lifelong adherence to a gluten\u2010free diet (GFD) is the primary treatment for celiac disease (CeD). Concerns have been raised about increased exposure to contaminants in a GFD because rice, which naturally bioaccumulates arsenic and other environmental contaminants, is commonly used as a substitute for gluten. In this study, we aimed to determine whether elevated urinary arsenic and other heavy metal concentrations, previously observed after 6 months on a GFD, persisted after 12 months on a GFD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single\u2010center prospective longitudinal cohort study of children (age 2\u201318 years) with biopsy\u2010confirmed CeD who initiated a GFD between January and May 2022. The primary outcome was the change in urinary arsenic concentration between baseline diagnostic endoscopy and 12 months on a GFD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010one of the 35 (60%) participants provided a follow\u2010up sample. After 12 months on a GFD, total median urinary arsenic concentration returned to baseline (3.42 vs. 4.93\u2009\u03bcg\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.17). The median total nail arsenic collection did not differ significantly between endoscopy and 12 months on a GFD samples (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.56). Only urinary molybdenum concentration was increased between endoscopy and 12 months of a GFD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with CeD may have increased arsenic exposure as they transition to a GFD, but concentrations return to baseline within 1 year. Future studies are needed to identify dietary contributors and guide strategies to limit excess arsenic exposure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jpr3.70135","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T10:42:12Z","timestamp":1766745732000},"page":"315-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Return to baseline arsenic concentrations after 1 year on gluten\u2010free diet in children with celiac disease: A prospective cohort study"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2728-917X","authenticated-orcid":false,"given":"Nan","family":"Du","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Baek","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Rosen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Punshon","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Dartmouth College Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn A.","family":"Silvester","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Boston Children's Hospital Boston Massachusetts USA"},{"name":"Celiac Center, Division of Gastroenterology Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000502"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.0120"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.21379"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3961\/jpmph.14.035"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1408742"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.878280"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-014-0012-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.12810"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003117"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1408789"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781003187639"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5JA00049A"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25372-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.110286"},{"key":"e_1_2_9_16_1","unstructured":"R Core Team.R: A Language and Environment for Statistical Computing[computer program]. R Foundation for Statistical Computing;2023."},{"key":"e_1_2_9_17_1","unstructured":"Posit Team.RStudio: Integrated Development Environment for R[computer program]. Posit Software PBC;2023."},{"key":"e_1_2_9_18_1","unstructured":"Agency for Toxic Substances.Toxicological Profile for Arsenic. U.S. Department of Health and Human Services Public Health Service Agency for Toxic Substances and Disease Registry;2007."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-023-00402-x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.111028"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2019.108787"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-50506-5"},{"key":"e_1_2_9_23_1","unstructured":"National Center for Environmental Health.National Report on Human Exposure to Environmental Chemicals[Online database March 2022] [Data set]. Centers for Disease Control and Prevention;2021."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-019-02510-w"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c04584"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/33.5.1103"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/62.4.790"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0946-672X(01)80059-6"},{"key":"e_1_2_9_29_1","volume-title":"National Report on Human Exposure to Environmental Chemicals","author":"National Center for Environmental Health","year":"2022"},{"key":"e_1_2_9_30_1","volume-title":"Toxicological Profile for Molybdenum","author":"Agency for Toxic Substances and Disease Registry","year":"2020"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/2156587211406732"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-022-24805-9"}],"container-title":["JPGN Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jpr3.70135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jpr3.70135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:31:10Z","timestamp":1778153470000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jpr3.70135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/jpr3.70135"],"URL":"https:\/\/doi.org\/10.1002\/jpr3.70135","archive":["Portico"],"relation":{},"ISSN":["2691-171X","2691-171X"],"issn-type":[{"value":"2691-171X","type":"print"},{"value":"2691-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,26]]},"assertion":[{"value":"2025-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}